IL-4

Clinical significance of interleukin-4 and interleukin-18 levels in aggressive non-Hodgkin’s lymphoma patients

H. O. Soydinc, Guney, N., Basaran, M., Duranyildiz, D., Yasasever, V., Soydinc, H. O., Guney, N., Basaran, M., Duranyildiz, D., and Yasasever, V., “Clinical significance of interleukin-4 and interleukin-18 levels in aggressive non-Hodgkin’s lymphoma patients”, vol. 15, p. -, 2016.

Strong evidence indicates that tumor growth can be actively controlled by the immune system, and interleukins (ILs) are known to play an influential role in immune response regulation. Moreover, inflammatory cytokines are significantly involved in lymphoma pathogenesis. We aimed to investigate serum levels of IL-4 and IL-18 in aggressive non-Hodgkin’s lymphoma (A-NHL) patients and their relationship with prognostic parameters and therapy outcome.

Association of IL-4 promoter polymorphisms with asthma: a meta-analysis

L. Tang, Lin, H. G., and Chen, B. F., “Association of IL-4 promoter polymorphisms with asthma: a meta-analysis”, vol. 13, pp. 1383-1394, 2014.

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly associated with asthma; however, significant associations were found only in the European population.

Association of variable number of tandem repeat polymorphism in the IL-4 gene with ischemic stroke in the Chinese Uyghur population

Y. - Q. Tong, Ye, J. - J., Wang, Z. - H., Zhang, Y. - W., Zhan, F. - X., Guan, X. - H., Geng, Y. - J., Hou, S. - Y., Li, Y., Cheng, J. - Q., Lu, Z. - X., and Liu, J. - F., “Association of variable number of tandem repeat polymorphism in the IL-4 gene with ischemic stroke in the Chinese Uyghur population”, vol. 12, pp. 2423-2431, 2013.

Ischemic stroke (IS) is a multifactorial disorder, and genetic factors act as important contributors to its onset and progression. Inflammation is a key event that is closely associated with the pathophysiology of IS. The association of genetic polymorphisms of inflammatory cytokines with IS remains poorly understood. We investigated the relationship between the variable number of tandem repeats (VNTR) for IL-4, which is an important biomarker of inflammation, and the risk of IS.

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