Infections pancreatic necrosis virus

Characterization and expression analysis of Toll-like receptor 3 cDNA from Atlantic salmon (Salmo salar)

R. Vidal, González, R., and Gil, F., Characterization and expression analysis of Toll-like receptor 3 cDNA from Atlantic salmon (Salmo salar), vol. 14, pp. 6073-6083, 2015.

Innate pathway activation is fundamental for early anti-viral defense in fish, but currently there is insufficient understanding of how salmonid fish identify viral molecules and activate these pathways. The Toll-like receptor (TLR) is believed to play a crucial role in host defense of pathogenic microbes in the innate immune system. In the present study, the full-length cDNA of Salmo salar TLR3 (ssTLR3) was cloned. The ssTLR3 cDNA sequence was 6071 bp long, containing an open reading frame of 2754 bp and encoding 971 amino acids.

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