Interleukin-1β

Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis

D. Z. Chi, Chen, J., and Huang, D. P., “Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis”, vol. 14, pp. 975-980, 2015.

We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1β and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1β+3954 C/T (rs1143634) and IL-1β-511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796).

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Y. S. Wang, Liu, L., Xu, X. Y., Wang, J. L., Zhou, H., Li, T. L., and Liang, Z. A., “Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis”, vol. 14, pp. 4477-4484, 2015.

Studies examining the role of interleukin (IL)-1β -511C/T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This meta-analysis was performed to assess the association between the IL-1β-511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sectional, and cohort studies from Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.

Effects of eplerenone on the activation of matrix metalloproteinase-2 stimulated by high glucose and interleukin-1β in human cardiac fibroblasts

J. F. Chi, Uzui, H., Guo, H. Y., Ueda, T., and Lee, J. D., “Effects of eplerenone on the activation of matrix metalloproteinase-2 stimulated by high glucose and interleukin-1β in human cardiac fibroblasts”, vol. 13, pp. 4845-4855, 2014.

The aim of this study was to determine the influence of high glucose (HG) and interleukin (IL)-1β on human cardiac fibroblast (HCF) functions, and to evaluate the effects of eplerenone in these responses. HCFs were cultured in normal or HG media in the absence or presence of IL-1β and/or eplerenone. We assessed matrix metalloproteinase-2 (MMP-2) activity in the supernatant by in-gel zymography, and determined mRNA expression levels of MMP-2 and tissue inhibitor of metalloproteinase-2 (TIMP-2) by reverse transcription-polymerase chain reaction.

Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis

F. - L. Wu, Wang, L. - Y., Huang, Y. - Q., Guo, W. - B., Liu, C. - D., and Li, S. - G., “Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis”, vol. 12, pp. 4678-4686, 2013.

The purpose of this meta-analysis was to determine whether genetic variants of the interleukin-1β[+3954 C>T (rs1143634)] (IL-1β +3954 C>T) gene polymorphisms were associated with orthodontic external apical root resorption (EARR). A meta-analysis was carried out using data entered into the PubMed and Embase electronic databases before October 5, 2012. A total of 7 studies were identified for meta-analysis. The strength of the relationship between IL-1β +3954 C>T polymorphism and the risk of EARR was assessed using odds ratio (OR).

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