Interleukin-10

Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis

Y. - F. Yu, Han, Z. - G., Guo, W. - B., Zhang, G. - J., Yang, J. - K., Wu, F. - L., Ou, Q. - Y., Li, Y. - H., Cai, X. - Y., Zhan, Z. - N., Chen, J. - H., Xie, W. - L., Tang, L., and Liu, C. - D., “Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis”, vol. 14, pp. 18945-18957, 2015.

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort studies were quantitatively analyzed to evaluate IL-10 promoter gene polymorphisms and NPC risk.

Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia

Q. Y. Liu, Gao, F. Y., Liu, X. R., Li, J., Ji, M., Dong, J., and Wang, X. T., “Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia”, vol. 14, pp. 19323-19328, 2015.

In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in conformance with Hardy-Weinberg equilibrium (HWE; P = 0.46 and 0.17).

Interleukin-10 polymorphisms associated with susceptibility to acute myeloid leukemia

C. Fei, Yao, X. M., Sun, Y., Gu, X. Z., Yu, L. Q., and Lai, X., “Interleukin-10 polymorphisms associated with susceptibility to acute myeloid leukemia”, vol. 14, pp. 925-930, 2015.

We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) and the risk of acute myeloid leukemia (AML) in a Chinese population. A total of 167 primary AML cases and 328 healthy control subjects were recruited at the First People’s Hospital of Yunnan Province between March 2009 and January 2012. The polymorphisms rs1800896, rs1800871, and rs1800872 were genotyped by polymerase chain reaction-restriction fragment length polymorphism.

Effects of musk ketone on nerve recovery after spinal cord injury

L. Guo, Quan, Z. X., Zhao, Z. H., Tang, K., Ou, Y. S., and Jiang, D. M., “Effects of musk ketone on nerve recovery after spinal cord injury”, vol. 14, pp. 2958-2963, 2015.

The present study aimed to determine the effects of musk ketone on nerve recovery in rats after spinal cord injury. A total of 105 SD female rats were used to establish the rat with dorsal spinal cord injury model (modified Allen’s method). The rats weighed from 200 to 250 g and were provided by the Experimental Animal Center of Chongqing Medical University. They were randomly divided into five treatment groups: saline (NS group), methylprednisolone (MP group), and musk ketone groups (MO1, MO2, and MO3 groups).

IL-10 and IL-12B gene polymorphisms in a multiethnic Malaysian population

S. S. Sam, Teoh, B. T., and AbuBakar, S., “IL-10 and IL-12B gene polymorphisms in a multiethnic Malaysian population”, vol. 14, pp. 3257-3263, 2015.

Inheritance of polymorphisms in the interleukin (IL)-10 promoter and IL-12B genes, which influence cytokine production and activities, may define the balance in T helper response in infection and autoimmune diseases. In the present study, we investigated the distribution of the IL-10 promoter and IL-12B gene polymorphisms in a multiethnic Malaysian population.

Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery

Z. - M. Xing, Zhang, Z. - Q., Zhang, W. - S., and Liu, Y. - F., “Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery”, vol. 14, pp. 4778-4783, 2015.

This study aimed to discuss the effects of 3 different analgesia methods on serum IL-6 and IL-10 in patients after cesarean delivery. Thirty full-term women, who underwent cesarean delivery, were randomly assigned to 3 analgesia groups (10 cases each) as follows: intramuscular injection of 100 mg pethidine (NC group), patient controlled epidural analgesia (PCEA) of 5 mg morphine plus 150 mg ropivacaine (MR group), and patient controlled intravenous analgesia (PCIA) of 150 mg sufentanil plus 5 mg droperidol (SF group). An electronic analgesia pump was available in all 3 groups.

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

F. M. Feng, Liu, X. X., Sun, Y. H., Zhang, P., Sun, S. F., Zhang, B., Wang, X. T., and Lu, L. J., “Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population”, vol. 13, pp. 7766-7772, 2014.

We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.

Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer

M. Qi, Liu, D. M., Pan, L. L., and Lin, Y. X., “Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer”, vol. 13, pp. 8954-8961, 2014.

Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify relevant studies. A meta-analysis was performed to examine the association between the interleukin-10 gene -592C>A polymorphism and gastric cancer risk.

Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea

F. Yu, Huang, S., Zhou, F., Luo, Q., Xie, X., and Zheng, C., “Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea”, vol. 13, pp. 10285-10293, 2014.

We examined patients of Han nationality diagnosed with irritable bowel syndrome with diarrhea (IBS-D) in Guangdong, China, to analyze the correlation between DQB1 allele polymorphisms and the genetic susceptibility to IBS-D. A total of 120 IBS-D patients of Han nationality in Guangdong, China, and 60 healthy control volunteers were included. DQB1 allele polymorphisms were investigated by polymerase chain reaction. Subjects’ serum interleukin (IL)-10 level, colonic permeability, and tight junction marker zonula occludens 1 (ZO1) mRNA level were also investigated.

Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk

Y. M. Zhang, Zhou, X. C., Xu, Z., and Tang, C. J., “Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk”, vol. 11, pp. 3389-3397, 2012.

In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls.

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