Interleukin 18

Molecular cloning, characterization, and ioactivity analysis of interleukin 18 in giant panda (Ailuropoda melanoleuca)

Y. Yan, Wang, Q., Niu, L. L., Deng, J. B., Yu, J. Q., Zhang, Y. Z., Wang, J. X., Yin, M. M., and Tan, X. M., Molecular cloning, characterization, and ioactivity analysis of interleukin 18 in giant panda (Ailuropoda melanoleuca), vol. 13, pp. 9687-9700, 2014.

Interleukin 18 (IL-18), as a member of IL-1 superfamily, is an important pleiotropic cytokine that modulates Th1 immune responses. In this report, we cloned and identified a homolog of IL-18 in giant panda (Ailuropoda melanoleuca) (designated as AmIL-18) from peripheral blood mononuclear cells stimulated with lipopolysaccharide. The open readin g frame of AmIL-18 cDNA is 579 bp encoding a deduced protein of 192 amino acids. AmIL-18 gDNA fragments contained 5 exons and 4 introns.

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