Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer
“Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer”, vol. 14, pp. 8490-8495, 2015.
, Previous study has shown that miR-122, miR-378, and their target gene IL1A may play crucial roles in the tumorigenesis of colorectal cancer (CRC). An insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of IL1A has been identified as a contributing factor to the risk of developing several cancers. The aim of this study was to evaluate the effect of IL1A rs3783553 on CRC risk. CRC patients (N = 339) and healthy control subjects (N = 313) were enrolled and genomic DNA was extracted from peripheral venous blood.