Interleukin-1A; Polymorphism; Colorectal cancer

Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer

H. Yan, Sun, R., Pan, X., Li, Z., Guo, X., and Gao, L., Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer, vol. 14, pp. 8490-8495, 2015.

Previous study has shown that miR-122, miR-378, and their target gene IL1A may play crucial roles in the tumorigenesis of colorectal cancer (CRC). An insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of IL1A has been identified as a contributing factor to the risk of developing several cancers. The aim of this study was to evaluate the effect of IL1A rs3783553 on CRC risk. CRC patients (N = 339) and healthy control subjects (N = 313) were enrolled and genomic DNA was extracted from peripheral venous blood.

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