Interleukin-24

Expression and effect of serum interleukin-24 level on bone marrow mononuclear cells in children with acute leukemia

H. R. Cheng, Wu, B. Q., Chen, L., Zhang, Z. X., and Li, B., Expression and effect of serum interleukin-24 level on bone marrow mononuclear cells in children with acute leukemia, vol. 14, pp. 17281-17288, 2015.

To investigate the expression of interleukin-24 (IL-24) in the children with acute leukemia (AL) and its effect on the apoptosis of bone marrow mononuclear cells (BMMNCs) in vitro. Four groups were assessed: acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), non-leukemia, and healthy groups, 20 children in each group. ELISA was used to measure IL-24 serum level. The bone marrow was taken from patients and controls. BMMNCs were isolated and the DNA was analyzed by glucose electrophoresis. Flow cytometry was used to determine BMMNC apoptosis.

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