Interleukin-6

Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis

Y. Liu, Song, X. L., Zhang, G. L., Peng, A. M., Fu, P. F., Li, P., Tan, M., Li, X., Li, M., and Wang, C. H., “Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis”, vol. 14, pp. 163-169, 2015.

The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized the Q-test and I2 test to determine heterogeneity between each study.

Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis

D. Z. Chi, Chen, J., and Huang, D. P., “Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis”, vol. 14, pp. 975-980, 2015.

We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1β and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1β+3954 C/T (rs1143634) and IL-1β-511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796).

Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease

K. Wang, Dong, P. S., Zhang, H. F., Li, Z. J., Yang, X. M., and Liu, H., “Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease”, vol. 14, pp. 3177-3183, 2015.

We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 ˗174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polymerase chain reaction-restriction fragment length polymorphism.

Neuroprotective effect of ketamine on acute spinal cord injury in rats

S. H. Tang, Yu, J. G., Li, J. J., and Sun, J. Y., “Neuroprotective effect of ketamine on acute spinal cord injury in rats”, vol. 14, pp. 3551-3556, 2015.

The aim of this study was to investigate the neuroprotective effects of ketamine during acute spinal cord injury in rats. Sprague Dawley (SD) rats (N = 70) were randomly divided into three groups: sham-operated (N = 10), control (N = 30), and treatment (N = 30) groups. The moderate spinal cord injury model was established. After injury, the sham-operated group received no drug, the treatment group received intraperitoneal ketamine injections, and the control group received intraperitoneal normal saline injections.

Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis

S. Y. Wang, Li, Z. J., Wang, X., Li, W. F., and Lin, Z. F., “Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis”, vol. 14, pp. 4344-4353, 2015.

The aim of this study was to investigate the influence of ulinastatin (UTI) on high mobility group box 1 (HMGB1), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 expression in acute lung injury (ALI) rats with sepsis caused by cecal ligation and puncture (CLP) surgery, as well as to examine the underlying biological mechanism. Thirty rats were randomly and evenly divided into sham (control), CLP, and CLP + UTI groups.

Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery

Z. - M. Xing, Zhang, Z. - Q., Zhang, W. - S., and Liu, Y. - F., “Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery”, vol. 14, pp. 4778-4783, 2015.

This study aimed to discuss the effects of 3 different analgesia methods on serum IL-6 and IL-10 in patients after cesarean delivery. Thirty full-term women, who underwent cesarean delivery, were randomly assigned to 3 analgesia groups (10 cases each) as follows: intramuscular injection of 100 mg pethidine (NC group), patient controlled epidural analgesia (PCEA) of 5 mg morphine plus 150 mg ropivacaine (MR group), and patient controlled intravenous analgesia (PCIA) of 150 mg sufentanil plus 5 mg droperidol (SF group). An electronic analgesia pump was available in all 3 groups.

Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome

X. H. Wang, Liu, S. Q., Wang, Y. L., and Jin, Y., “Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome”, vol. 13, pp. 4260-4266, 2014.

Serum high-sensitivity C-reactive protein (hs-CRP) is a sensitive indicator of inflammation, which is closely related with the progress of plaque formation. Interleukin-6 (IL-6) is one of the inflammatory markers of local coronary plaque and the peripheral blood cycle, promoting the occurrence of atherosclerosis development and plaque rupture. In this study, the correlation of hs-CRP and IL-6 was investigated in patients with acute coronary syndrome (ACS).

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

G. Q. Sun, Wu, G. D., Meng, Y., Du, B., and Li, Y. B., “IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population”, vol. 13, pp. 7718-7724, 2014.

We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) was performed on a 384-well plate format using the Sequenom MassARRAY platform.

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

F. M. Feng, Liu, X. X., Sun, Y. H., Zhang, P., Sun, S. F., Zhang, B., Wang, X. T., and Lu, L. J., “Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population”, vol. 13, pp. 7766-7772, 2014.

We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.

Acanthopanax senticosus attenuates inflammation in lipopolysaccharide-induced acute lung injury by inhibiting the NF-κB pathway

X. J. Fei, Zhu, L. L., Xia, L. M., Peng, W. B., and Wang, Q., “Acanthopanax senticosus attenuates inflammation in lipopolysaccharide-induced acute lung injury by inhibiting the NF-κB pathway”, vol. 13, pp. 10537-10544, 2014.

The dried roots of the plant Acanthopanax senticosus (AS) are used in traditional Oriental medicine and reportedly possess anti-inflammatory properties in vitro. However, whether AS has the same anti-inflammatory effect in vivo and the underlying mechanisms of this action remain unknown.

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