Interleukin-6

Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis

Q. Zhao, Zhang, B., Chen, Y., Li, M., Zhao, X., Fan, H., and Li, S. M., Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis, vol. 14, pp. 16921-16928, 2015.

The -572G/C polymorphism in interleukin-6 (IL-6) gene is associated with the development of cancer. However, previous studies have shown conflicting results; therefore, the association must be verified by an appropriate meta-analysis. For this purpose, we performed a literature search of the PubMed database to identify all reports on association between the IL-6 -572G/C polymorphism and cancer risk. Summary odds ratios (OR) and 95% confidence intervals (95%CI) were calculated for the -572G/C polymorphism and cancer in a fixed- and random-effect model, as appropriate.

Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis

Q. B. Yu, Li, H. M., Li, L. L., Wang, S. Y., and Wu, Y. B., Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis, vol. 14, pp. 19016-19027, 2015.

This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB). The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used.

Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

X. M. Xie, Ke, R., Zhang, Y. H., Wang, G. Z., Zhu, Y. T., Hussian, T., Yang, L., and Li, M. X., Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis, vol. 14, pp. 8516-8525, 2015.

Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Knowledge Infrastructure (CNKI) databases for published studies investigating the associations between IL-6 -174G>C polymorphism and COPD.

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