Intervertebral disc

Small molecule-enrichment analysis in response to osmotic stimuli in the intervertebral disc

H. Ma, Xie, Y. Z., Zhao, J., and Ye, B., Small molecule-enrichment analysis in response to osmotic stimuli in the intervertebral disc, vol. 11, pp. 3668-3675, 2012.

The intervertebral disc (IVD) is a heterogeneous structure that contributes to load support and flexibility in the spine. IVD cells experience a broad range of physical stimuli under physiological conditions, including alterations in their osmotic environment. To date, the molecular mechanisms regulating the response of IVD to osmotic pressure are still not well understood. We obtained the gene expression profile of human IVD cells from NCBI and looked for potential therapeutic drug candidates.

Text-mining network analysis of the response to osmotic stimuli in the intervertebral disc

X. Xu, Liu, L., and Lu, Q. Y., Text-mining network analysis of the response to osmotic stimuli in the intervertebral disc, vol. 12, pp. 1574-1581, 2013.

Intervertebral disc cells experience a broad range of physical stimuli under physiologic conditions, including alterations in their osmotic environment. The purpose of this study was to construct a text-mining network of the genes induced during the response to osmotic stimuli in the intervertebral disc.

Co-transfection of adeno-associated virus-mediated human vascular endothelial growth factor165 and transforming growth factor-β1 into annulus fibrosus cells of rabbit degenerative intervertebral discs

Y. M. Xi, Dong, Y. F., Wang, Z. J., Liu, Y., Diao, Z. Z., and Hu, Y. G., Co-transfection of adeno-associated virus-mediated human vascular endothelial growth factor165 and transforming growth factor-β1 into annulus fibrosus cells of rabbit degenerative intervertebral discs, vol. 12, pp. 4895-4908, 2013.

Intervertebral disc degeneration is a common condition that may lead to low back pain and radiculopathy. Understanding the pathophysiology and cellular and molecular events of degenerative disc disease has resulted in the proposal of a gene therapy approach to halt and reverse disc degeneration. We explored the feasibility of reversing intervertebral disc degeneration using human vascular endothelial growth factor165 (hVEGF165) and transforming growth factor-β1 (TGF-β1) gene therapy.

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