Relationship between UV-irradiated HaCaT cell cytokines and Th1/Th2 imbalance
“Relationship between UV-irradiated HaCaT cell cytokines and Th1/Th2 imbalance”, vol. 14, pp. 7976-7985, 2015.,
We have previously found that an imbalance of Tc1/Tc2 T cell subtypes in vivo impacts the development of photodermatitis. The aim of this study was to investigate the relationship between cytokines derived from keratinocytes exposure to UV and the imbalance of Th subgroups. We used different doses of UVA and UVB to irradiate HaCaT cells. Twelve hours after irradiation, the expression of IL-10R, IL-4R, IL-12R, and IFN-γR proteins was observed using the S-P method, and the percentage of positive cells calculated.