Ischemia-reperfusion injury

Protective effect of ischemia preconditioning on ischemia-reperfusion injury in rat liver transplantation

Z. S. Qing, Zhang, X. S., Gao, C. C., Liu, W. D., Xia, T. F., Wu, K., and Pang, L. Q., Protective effect of ischemia preconditioning on ischemia-reperfusion injury in rat liver transplantation, vol. 14, pp. 3018-3025, 2015.

We explored the protective effect of ischemia preconditioning (IP) on ischemia-reperfusion injury in rat liver transplantation. An orthotopic liver transplantation model was utilized in the study. A total of 54 Sprague-Dawley rats were divided into a control group (group A, no liver transplantation), liver transplantation group (group B, heparin Ringer’s lactate solution was perfused via the portal vein before donor liver collection), and liver transplantation with IP group (group C, IP was performed for different time periods before donor liver collection).

Effects of autologous SCF- and G-CSF-mobilized bone marrow stem cells on hypoxia-inducible factor-1 in rats with ischemia-reperfusion renal injury

L. Y. Bi, Zhao, D. A., Yang, D. S., Guo, J. G., Liang, B., Zhang, R. X., Zhao, J. L., Bai, H. T., and Li, S. J., Effects of autologous SCF- and G-CSF-mobilized bone marrow stem cells on hypoxia-inducible factor-1 in rats with ischemia-reperfusion renal injury, vol. 14, pp. 4102-4112, 2015.

To explore the mechanism whereby stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) jointly mobilize bone marrow stem cells (BMSCs) and promote kidney repair, male Sprague-Dawley rats were randomly assigned into 4 groups. In the treatment control group, rats were administered SCF (200 μg·kg-1·day-1) and G-CSF (50 μg·kg-1·day-1) for 5 days. In the treatment group, RIRI models were established, and 6 h later, SCF (200 μg·kg-1·day-1) and G-CSF (50 μg·kg-1·day-1) were administered for 5 days.

Effects of different doses of Savda Munziq on myocardial ischemia-reperfusion injury in rats with abnormal Savda syndrome

A. Maimaitiaili, Shabiti, A., Abudureheman, M., Musha, Z., Jun, Q., Maimaitiaili, G., Aibibula, A., and Upur, H., Effects of different doses of Savda Munziq on myocardial ischemia-reperfusion injury in rats with abnormal Savda syndrome, vol. 13, pp. 4729-4735, 2014.

To investigate the effects of different doses of abnormal Savda Munziq on myocardial ischemia-reperfusion injury (MI/RI) in rats with the abnormal Savda syndrome, 50 abnormal Savda animal models were randomly divided into a control group, a model group, a high-dose group, a middle-dose group, and a low-dose group, with each group containing 10 rats. The enzyme-linked immunosorbent assay was used to detect the serum myocardial enzyme and troponin levels, and hematoxylin and eosin (HE) staining was used to observe changes of the myocardial tissues in the different groups.

Application of ultrasound technology in the study of ischemic postconditioning to protect testes from ischemia-reperfusion injury

E. S. Xue, Chen, Q. Q., Wang, Y., Zhang, Y., Chen, S., and Liang, R. X., Application of ultrasound technology in the study of ischemic postconditioning to protect testes from ischemia-reperfusion injury, vol. 13, pp. 6937-6948, 2014.

This study was designed to investigate the application of ultrasound technology in the study of ischemic postconditioning to protect testes from ischemia-reperfusion injury. Seventy-two big white rabbits were divided into mild ischemic groups (Group A: A0, A1, A2, A3), moderate ischemic groups (Group B: B0, B1, B2, B3) under ultrasound monitor, and control group (N = 8). Groups A0 and B0 received direct perfusion, while the other groups received a different short time filling/stopped filling treatment (15 s/15 s, 30 s/30 s, or 45 s/45 s) three times before complete perfusion.

Cardioprotective effects mitochondrial ATP-sensitive potassium channel in exercise conditioning

F. - L. Peng, Guo, Y. - J., Mo, W. - B., Xu, S. - M., and Liao, H. - P., Cardioprotective effects mitochondrial ATP-sensitive potassium channel in exercise conditioning, vol. 13, pp. 7503-7512, 2014.

We investigated the mitochondrial ATP-sensitive potassium channel [mito-K (ATP)] in exercise preconditioning of myocardial ischemia-reperfusion injury in rats. Eighty SD rats were randomly divided into high-, moderate-, low-intensity, and control groups. The exercise groups were divided into control and inhibited groups. The control group was divided into model and sham groups. Eight rats were randomly selected from each group for analysis.

Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats

S. M. Yang, Liu, J., and Li, C. X., Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats, vol. 13, pp. 8309-8319, 2014.

Hyperlipidemia is a well-established risk factor for the development of coronary atherosclerosis, while intermedin (IMD) has been identified as a novel calcitonin/calcitonin gene-related peptide family member involved in cardiovascular protection. However, whether IMD protects against hyperlipidemia-associated myocardial ischemia/reperfusion (MI/R) injury is unknown. We established a hyperlipidemia model using Sprague-Dawley rats, and created a MI/R condition by ligating the cardiac left circumflex artery.

Subscribe to Ischemia-reperfusion injury