Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts
, “Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts”, vol. 8, pp. 129-143, 2009.
Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as inflammation and DNA damage and end with the development of cancer.
