Jurkat/ADR

Reversal effect of vitamin D on different multidrug-resistant cells

M. Yan and Nuriding, H., Reversal effect of vitamin D on different multidrug-resistant cells, vol. 13, pp. 6239-6247, 2014.

We investigated the reversal effect of vitamin D on the multidrug-resistant leukemic Jurkat/ADR and K562/ADR cell lines and conducted a preliminary investigation of its reversal mechanism. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method was used to detect the reversal effect of vitamin D on multidrug-resistant cells. Real-time polymerase chain reaction was used to determine the effect of vitamin D on intracellular expression of mRNA of the multidrug-resistant gene (MDRI) and the multidrug-resistance-related gene (MRP1).

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