K+-ATPase

Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle

Y. X. Liu, Xu, C. H., Gao, T. Y., and Sun, Y., Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle, vol. 11, pp. 651-660, 2012.

Mastitis affects the concentrations of potassium and sodium in milk. Since sodium-potassium adenosine triphosphatase (Na+, K+-ATPase) is critical for maintaining the homeostasis of these two ions, and is involved in cell apoptosis and pathogenesis, we presumed that polymorphism of the ATP1A1 gene, which encodes the bovine Na+, K+-ATPase α1 subunit could be associated with mastitis.

Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle

Y. X. Liu, Zhou, X., Li, D. Q., Cui, Q. W., and Wang, G. L., Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle, vol. 9. pp. 891-896, 2010.

Heat stress produces oxidative stress and affects the alternation of plasma K+ and Na+. Since Na+,K+-ATPase is sensitive to oxidative stress and critical for maintaining the homeostasis of these two ions, we examined the genetic polymorphism of the ATP1A1 gene in 160 Holstein cows using polymerase chain reaction low ionic strength single-strand conformation polymorphism and DNA sequencing methods.

Subscribe to K+-ATPase