Keratinocyte migration

Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an “eye open at birth” phenotype

L. C. Wu, Liu, C., Jiang, M. R., Jiang, Y. M., Wang, Q. H., Lu, Z. Y., Wang, S. J., Yang, W. L., Shao, Y. X., Wu, L. C., Liu, C., Jiang, M. R., Jiang, Y. M., Wang, Q. H., Lu, Z. Y., Wang, S. J., Yang, W. L., and Shao, Y. X., Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an “eye open at birth” phenotype, vol. 15, p. -, 2016.

Development of the eyelid requires coordination of the cellular processes involved in proliferation, cell size alteration, migration, and cell death. C57BL/6J-corneal opacity (B6-Co) mice are mutant mice generated by the administration of N-ethyl-N-nitrosourea (100 mg/kg). They exhibit the eyelids open at birth phenotype, abnormal round cell shape from tightened F-actin bundles in leading edge keratinocytes at E16.5, and gradual corneal opacity with neovessels.

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