Leptin receptor

RNA interference of leptin receptor in chicken adipocytes

A. X. Huang, Li, J. J., Tian, Y., Shen, J. D., Tao, Z. R., Li, G. Q., Lu, L. Z., Fu, Y., and Wu, T. X., “RNA interference of leptin receptor in chicken adipocytes”, vol. 13, pp. 5901-5907, 2014.

In this study, chicken adipocytes were cultured to evaluate RNA interference by the leptin receptor gene. A small interfering RNA of the leptin receptor gene was synthesized, with a suppression rate of 60% being generated (P peroxisome proliferator-activated receptor γ, fatty acid synthase, adipose triglyceride lipase, and lipoprotein lipase. In addition, a significant increase in the expression of the adiponectin gene was documented.

Comparative study of leptin and leptin receptor gene expression in different swine breeds

S. E. Georgescu, Manea, M. A., Dinescu, S., and Costache, M., “Comparative study of leptin and leptin receptor gene expression in different swine breeds”, vol. 13, pp. 7140-7148, 2014.

Leptin is an important regulator of appetite, energy metabolism, and reproduction and is mainly synthesized in the adipocytes and then secreted into the bloodstream. The leptin receptor was classified as type I cytokine receptor due to its structural homology with IL-6 receptors and the signaling pathways in which they are both involved.

High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia

S. Wang, Qiao, F. Y., and Feng, L., “High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia”, vol. 12, pp. 2416-2422, 2013.

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and Lys656Asn + Asn656Asn frequencies in the LEPR gene were significantly more prevalent in preeclampsia mothers than in controls (P

LEPR p.Q223R, β3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects

S. F. P. Duarte, Francischetti, E. A., Genelhu, V. A., Cabello, P. H., and Pimentel, M. M. G., “LEPR p.Q223R, β3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects”, vol. 6, pp. 1035-1043, 2007.

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have been controversial.

Subscribe to Leptin receptor