Linkage analysis

Linkage and mapping analyses of the normal marking gene +P in the silkworm (Bombyx mori) using SSR markers

G. Q. Wei, Yu, L., Liu, C. L., Zhu, B. J., and Ding, H. J., “Linkage and mapping analyses of the normal marking gene +P in the silkworm (Bombyx mori) using SSR markers”, vol. 12, pp. 2351-2359, 2013.

In the silkworm, Bombyx mori, normal markings are mainly controlled by the +P gene, which is located on the second chromosome. Due to a lack of crossing over in females, reciprocal backcrossed F1 (BC1) progenies were used for linkage analysis and mapping of the +P gene based on an SSR linkage map using silkworm strains P50 and H9, which are normal marking and sex-limited marking, respectively. The +P gene was found to be linked to 3 SSR markers.

Segregation and genetic linkage analyses of river catfish, Mystus nemurus, based on microsatellite markers

B. P. Hoh, Siraj, S. S., Tan, S. G., and Yusoff, K., “Segregation and genetic linkage analyses of river catfish, Mystus nemurus, based on microsatellite markers”, vol. 12, pp. 2578-2593, 2013.

The river catfish Mystus nemurus is an important fresh water species for aquaculture in Malaysia. We report the first genetic linkage map of M. nemurus based on segregation analysis and a linkage map using newly developed microsatellite markers of M. nemurus. A total of 70 of the newly developed polymorphic DNA microsatellite markers were analyzed on pedigrees generated using a pseudo-testcross strategy from 2 mapping families.

Genetic linkage analysis of oral lichen planus in a Chinese family

Z. Wang, Yao, H., Cui, B., Ning, G., and Tang, G. Y., “Genetic linkage analysis of oral lichen planus in a Chinese family”, vol. 10, pp. 1427-1433, 2011.

Oral lichen planus (OLP) is a common oral inflammatory disease affecting about 1-2% of the general adult population. As with European families who are diagnosed with OLP, the Chinese family who we studied was diagnosed with a severe form of oral reticular and erosive lesions; moreover, two of the five affected individuals developed oral cancer at an early age.

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