Lipase

Association of serum adipose triglyceride lipase levels with obesity and diabetes

L. Yang, Chen, S. J., Yuan, G. Y., Zhou, L. B., Wang, D., Wang, X. Z., and Chen, J. J., Association of serum adipose triglyceride lipase levels with obesity and diabetes, vol. 13, pp. 6746-6751, 2014.

The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were divided into an overweight or obese subgroup and a normal weight subgroup according to body mass index (BMI) ≥ 25 kg/m2. The enzyme-linked immunosorbent assay was used to detect fasting blood glucose, blood lipids, fasting insulin, and ATGL levels.

Isolation of a novel lipase from a metagenomic library derived from mangrove sediment from the south Brazilian coast

G. H. Couto, Glogauer, A., Faoro, H., Chubatsu, L. S., Souza, E. M., and Pedrosa, F. O., Isolation of a novel lipase from a metagenomic library derived from mangrove sediment from the south Brazilian coast, vol. 9, pp. 514-523, 2010.

A novel gene coding for a LipA-like lipase with 283 amino acids and a molecular mass of 32 kDa was isolated and characterized from a metagenomic library prepared from mangrove sediment from the south Brazilian coast. LipA was 52% identical to a lipolytic enzyme from an uncultured bacterium and shared only low identities (≤31%) with lipases/esterases from cultivable microorganisms.

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