Lipid metabolism

Gene expression profiles of primary retinal pigment epithelial cells from apolipoprotein E knockout and human apolipoprotein E2 transgenic mice

D. H. Jo, Lee, J. H., Jun, H. J., Kim, J., Wen, Q., Hoang, M. H., Yu, Y. S., Kim, J. H., Kim, J. H., and Lee, S. J., “Gene expression profiles of primary retinal pigment epithelial cells from apolipoprotein E knockout and human apolipoprotein E2 transgenic mice”, vol. 14, pp. 1855-1867, 2015.

Age-related macular degeneration (AMD) causes visual impairment in the elderly. In non-neovascular AMD, studies involving human subjects have suggested potential involvement of aberrant lipid metabolism. However, there have been no reports on gene expression patterns in animal models of non-neovascular AMD with abnormal lipid metabolism such as apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. Transcriptome analysis was performed using retinal pigment epithelium cells of apoE knockout and apolipoprotein E2 mice using microarray analysis.

Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women

H. Lin, Yin, Z., Yu, X. Y., Lin, N., Lin, Y., Chen, J., Chen, Y. Z., Lu, K. P., and Liu, H. K., “Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women”, vol. 13, pp. 6126-6134, 2014.

We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) were recruited and genotyped using polymerase chain reaction-restriction fragment length polymorphism for the two LIPC single nucleotide polymorphisms (SNPs).

RNA interference of leptin receptor in chicken adipocytes

A. X. Huang, Li, J. J., Tian, Y., Shen, J. D., Tao, Z. R., Li, G. Q., Lu, L. Z., Fu, Y., and Wu, T. X., “RNA interference of leptin receptor in chicken adipocytes”, vol. 13, pp. 5901-5907, 2014.

In this study, chicken adipocytes were cultured to evaluate RNA interference by the leptin receptor gene. A small interfering RNA of the leptin receptor gene was synthesized, with a suppression rate of 60% being generated (P peroxisome proliferator-activated receptor γ, fatty acid synthase, adipose triglyceride lipase, and lipoprotein lipase. In addition, a significant increase in the expression of the adiponectin gene was documented.

Association of the CD36 gene with impaired glucose tolerance, impaired fasting glucose, type-2 diabetes, and lipid metabolism in essential hypertensive patients

Y. Wang, Zhou, X. O., Zhang, Y., Gao, P. J., and Zhu, D. L., “Association of the CD36 gene with impaired glucose tolerance, impaired fasting glucose, type-2 diabetes, and lipid metabolism in essential hypertensive patients”, vol. 11, pp. 2163-2170, 2012.

Essential hypertension is a common disorder that can increase the risk of type 2 diabetes (T2D). CD36 has been studied in patients with diabetes and hypertension extensively; however, few studies have focused on the relationship of the CD36 gene with impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) or T2D in essential hypertension patients.

Effect of dietary Bacillus subtilis on proportion of Bacteroidetes and Firmicutes in swine intestine and lipid metabolism

C. Cui, Shen, C. J., Jia, G., and Wang, K. N., “Effect of dietary Bacillus subtilis on proportion of Bacteroidetes and Firmicutes in swine intestine and lipid metabolism”, vol. 12, pp. 1766-1776, 2013.

The ratio of Bacteroidetes and Firmicutes bacterial groups in the gut can affect the ability to absorb nutrients. We investigated the effect of probiotic Bacillus subtilis supplementation of diets on growth performance, fat deposition, blood lipids, copy numbers, and percentage of Bacteroidetes and Firmicutes in cecal contents, as well as mRNA expression of key lipid metabolism enzymes in the liver and adipose tissue of finishing pigs.

Global comparison of gene expression between subcutaneous and intramuscular adipose tissue of mature Erhualian pig

W. X. Sun, Wang, H. H., Jiang, B. C., Zhao, Y. Y., Xie, Z. R., Xiong, K., and Chen, J., “Global comparison of gene expression between subcutaneous and intramuscular adipose tissue of mature Erhualian pig”, vol. 12, pp. 5085-5101, 2013.

Adipose tissue plays an important role in energy metabolism and related diseases. The content of intramuscular fat significantly influences the pork quality. In this study, the whole gene expression of dorsal subcutaneous (s.c.) adipose tissue and intramuscular (i.m.) adipose tissue isolated from longissimus dorsi muscle tissue were compared using Affymetrix Gene-Chip microarray technology. The result revealed that 1228 genes were more highly expressed in s.c. adipose tissue, whereas 965 genes were higher expressed in i.m. adipose tissue. We found that the s.c.

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