Lipopolysaccharide

Relationship between liver and low rumen pH in goat

Z. Xie, Jiang, X., Ye, P., Zhang, Y., Ni, Y., Zhuang, S., and Shen, X., “Relationship between liver and low rumen pH in goat”, vol. 14, pp. 209-221, 2015.

The aim of this study was to analyze the response of dry goat liver to sub-acute ruminal acidosis induced by a highly concentrated diet. Non-pregnant, non-lactating female Poll-goats (N = 12) were randomly assigned to either a high-concentrate (HG) or a low-concentrate (LG) diet. Low rumen pH was successfully induced with HG (more than 3 h with rumen pH S-transferase was downregulated in the HG group, whereas aldo-keto reductase was upregulated compared in the LG group.

Expression of β-defensins in intestines of chickens injected with vitamin D3 and lipopolysaccharide

L. Lu, Li, S. M., Zhang, L., Liu, X. Q., Li, D. Y., Zhao, X. L., and Liu, Y. P., “Expression of β-defensins in intestines of chickens injected with vitamin D3 and lipopolysaccharide”, vol. 14, pp. 3330-3337, 2015.

The objective of this study was to evaluate the effect of vitamin D3 (VD3) on the regulation of chicken intestinal β-defensin genes under normal and lipopolysaccharides (LPS) conditions. Four treatment groups were used, including a negative control group, VD3-injection group, LPS-injection group, and both VD3-injection and LPS-injection group.

Attenuated mRNA expression of lipid metabolism genes in primary hepatocytes following lipopolysaccharide treatment in dairy cows

Y. Y. Wang, Li, H. P., Wang, X. J., Jiang, Q. D., Geng, J., Wang, L. F., Guo, Y. J., Lu, W. F., Zhu, H. S., and Yang, G. Y., “Attenuated mRNA expression of lipid metabolism genes in primary hepatocytes following lipopolysaccharide treatment in dairy cows”, vol. 14, pp. 3718-3728, 2015.

The influence of ruminal acidosis on ruminal microbiology and metabolite production has received considerable attention, but little is known regarding the systemic manifestations that arise from ruminal acidosis. Lipopolysaccharide (LPS) is released in the gastrointestinal tract upon ingestion of high-grain or high-fat diets, and it has been implicated in the etiology of multiple energy- and lipid-related metabolic disturbances in ruminants. The liver plays a crucial role in the acute phase response to intruding pathogens.

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

Y. Yu, Wang, W. N., Han, H. Z., Xie, K. L., Wang, G. L., and Yu, Y. H., “Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin”, vol. 14, pp. 6202-6212, 2015.

We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2, LPS, LPS+H2, H2, and LPS+H2 in saturated hydrogen-rich medium.

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