Liver transplantation

Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation

X. X. Zhang, Bian, R. J., Wang, J., Zhang, Q. Y., Zhang, X. X., Bian, R. J., Wang, J., Zhang, Q. Y., Zhang, X. X., Bian, R. J., Wang, J., and Zhang, Q. Y., “Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation”, vol. 15, p. -, 2016.

Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphisms in the genes encoding interleukin-10 (IL10), transforming growth factor-b1 (TGFB1), and tumor necrosis factor-a (TNF), and the risk of AR recurrence.

Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients

L. Wang, Liu, L. H., Tong, W. H., Wang, M. X., and Lu, S. C., “Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients”, vol. 14, pp. 15148-15157, 2015.

We examined the influence of the cytochrome P450 3A5 (CYP3A5) genes in both donors and recipients on the concentration-dosage ratio (C/D) of tacrolimus in Chinese liver transplant patients. Fifty-one adult liver transplant patients who received tacrolimus were included in this study. The CYP3A5 polymorphism in donors and recipients was determined at the time of transplantation, and tacrolimus-based immunosuppressive therapy was started based on each patient’s genetic constitution.

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