Longevity

Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan

A. M. Todd and Staveley, B. E., Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan, vol. 11, pp. 1497-1502, 2012.

Overexpression of the gene coding for α-synuclein has been shown to be an inherited cause of Parkinson disease. Our laboratory has previously co-expressed the parkin and Pink1 genes to rescue α-synuclein-induced phenotypes within a Drosophila model. To further investigate the effect of Pink1 in this model, we performed longevity and behavioral studies using several drivers to express the α-synuclein and Pink1 genes.

Experimental evaluation of the reproductive quality of Africanized queen bees (Apis mellifera) on the basis of body weight at emergence

D. A. De Souza, Bezzera-Laure, M. A. F., Francoy, T. M., and Gonçalves, L. S., Experimental evaluation of the reproductive quality of Africanized queen bees (Apis mellifera) on the basis of body weight at emergence, vol. 12, pp. 5382-5391, 2013.

There has been much speculation about which phenotypic traits serve as reliable indicators of productivity in queen honeybees (Apis mellifera). To investigate the predictive value of queen body weight on colony development and quality, we compared colonies in which queens weighed less than 180 mg to those in which queens weighed more than 200 mg. Both groups contained naturally mated and instrumentally inseminated queens. Colonies were evaluated on the basis of performance quality, growth rate, and queen longevity.

Survival of the thriftiest: restricted nurture reveals the thrifty nature of a growth gene in Bos indicus

S. U. Dani, Dani, M. A. C., Freire, I. L., Gouvea, S. P., Knackfuss, F. B., Lima, F. P., Mercadante, M. E. Z., Monteiro, E., Paggiaro, S. M. G., Razook, A. G., and Yehia, H. C., Survival of the thriftiest: restricted nurture reveals the thrifty nature of a growth gene in Bos indicus, vol. 9, pp. 1032-1044, 2010.

Growth hormone (GH) is a part of the somatotropic axis that controls metabolism, growth, development and aging in a wide range of animals. Mutations that reduce GH signaling have been associated with extended life spans and increased longevity in ways similar to what is observed in dietary restriction (DR) models. However, the mechanism by which DR works is not well understood. Here, we show that DR works as a factor in the evolution of the genetic make-up of domestic cattle.

Expression of GFP can influence aging and climbing ability in Drosophila

R. M. S. Mawhinney and Staveley, B. E., Expression of GFP can influence aging and climbing ability in Drosophila, vol. 10, pp. 494-505, 2011.

Green fluorescent protein (GFP) is widely used as a reporter transgene in a variety of organisms. Some of the advantages of using GFP include non-invasive visualization of biological events and/or tissues in live specimens and its benign nature. When GFP is expressed throughout the organism, in neurons and eyes, lifespan and climbing ability of flies are significantly decreased compared to similar crosses with a lacZ reporter. Also, GFP expression can have subtle effects on eye morphology, with neural and ubiquitous expression.

Apolipoprotein E polymorphism in elderly Japanese-Brazilian immigrants does not explain the reduced cardiovascular risk factor incidence

N. Terra, Moriguchi, Y., Bittencourt, L., Trois, R. S., Piccoli, J. E. C., and Cruz, I. B. M., Apolipoprotein E polymorphism in elderly Japanese-Brazilian immigrants does not explain the reduced cardiovascular risk factor incidence, vol. 10, pp. 1975-1985, 2011.

Study of immigrant populations may contribute to a better understanding of the epidemiology of diseases associated with the aging process. We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have lived in that region for over 40 years, versus a group of elderly, locally born Brazilians living in the same region. These Japanese subjects came to Brazil after World War II (1950-1960) from several Japanese cities, mainly Nagasaki, Kumamoto and Hokkaido.

Genetic parameters for productive life traits and reproductive efficiency traits at 6 years in Nellore cattle

J. C. C. Balieiro, Eler, J. P., Ferraz, J. B. S., Mattos, E. C., and Balieiro, C. C., Genetic parameters for productive life traits and reproductive efficiency traits at 6 years in Nellore cattle, vol. 7, pp. 1312-1318, 2008.

The objective of the present study was to estimate (co)variance components for length of productive life (LPL) and some alternative reproductive traits of 6-year-old Nellore cattle. The data set contained 57,410 records for age at first calving from Nellore females and was edited to remove animal records with uncertain paternity and cows with just one piece of calving information. Only animals with age at first calving ranging from 23 to 48 months and calving intervals between 11 and 24 months were kept for analysis. LPL and life production (LP) were used to describe productive life.

The effect of simulated censored data on estimates of heritability of longevity in the Thoroughbred racing industry

E. M. Burns, Enns, R. M., and Garrick, D. J., The effect of simulated censored data on estimates of heritability of longevity in the Thoroughbred racing industry, vol. 5, pp. 7-15, 2006.

We examined the impact of censored data on estimates of heritability of longevity. Longevity, defined as the length of productive racing life of an individual, is influenced by many factors. A simulated data set, modelled on the Irish Thoroughbred industry, was used to estimate heritabilities of longevity. Several scenarios representing various levels of censoring of performance data were created. The heritability of longevity was estimated for each scenario and compared to the estimated heritability of 0.120 for the complete data set.

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