Lung adenocarcinoma

Diagnosis of lymph node micrometastasis at the pN0 stage of lung adenocarcinoma using a combination of markers

H. Liu, Ye, Y. - K., Li, G. - M., Zhou, Y., Han, K. - B., Xu, G., and Wang, D., Diagnosis of lymph node micrometastasis at the pN0 stage of lung adenocarcinoma using a combination of markers, vol. 13, pp. 5594-5600, 2014.

This study aimed to detect micrometastatic tumor cells in the lymph nodes of patients with pN0 lung adenocarcinoma using a combination of thyroid transcription factor-1 (TTF-1) expression and cytokeratin 7 (CK7) expression and to investigate the association of lymph node micrometastasis with the clinicopathological characteristics of patients with lung adenocarcinoma. A total of 54 patients with pN0 lung adenocarcinoma and whose primary tumors were positive for both TTF-1 and CK7 expression were included in this study.

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

X. F. Chen, Cai, S., Chen, Q. G., Ni, Z. H., Tang, J. H., Xu, D. W., and Wang, X. B., Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma, vol. 11, pp. 370-378, 2012.

Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-control study in Shanghai was undertaken on 196 patients with lung cancer and 229 healthy individuals. TERT rs2736100 and CLPTM1L rs401681 and rs402710 were genotyped using the ABI TaqMan Allelic Discrimination assay.

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