Lung cancer

Association between the XPG gene Asp1104His polymorphism and lung cancer risk

B. Zhou, Hu, X. M., Wu, G. Y., Zhou, B., Hu, X. M., and Wu, G. Y., “Association between the XPG gene Asp1104His polymorphism and lung cancer risk”, vol. 15, p. -, 2016.

It has been suggested that the xeroderma pigmentosum complementation group G (XPG) gene Asp1104His polymorphism is linked to susceptibility to lung cancer. However, the results from the published studies are contradictory rather than conclusive. With this meta-analysis, we aimed to achieve a better understanding of the effects of the XPG gene Asp1104His polymorphism on lung cancer risk. We identified six eligible studies from five publications that included a total of 2293 lung cancer patients and 2586 controls.

Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population

J. J. Jin, Wang, H. Q., Kuang, H. P., Kang, B. B., Liu, Y. H., Wang, J., Jin, J. J., Wang, H. Q., Kuang, H. P., Kang, B. B., Liu, Y. H., and Wang, J., “Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population”, vol. 15, p. -, 2016.

Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility. A total of 703 subjects were recruited for this study. Genotyping of c.1804C>A genetic variant was performed using the created restriction site-polymerase chain reaction.

Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk

J. Ren, He, B. Z., Zhang, T. S., Lu, S. P., Yan, T., Ren, J., He, B. Z., Zhang, T. S., Lu, S. P., and Yan, T., “Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk”, vol. 15, p. -, 2016.

The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) in all selected studies were used to assess the relationship between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. The data was pooled using Stata v.11.

Changes in T-lymphocytes in lung cancer patients after hyperthermic intraperitoneal chemotherapy or radiotherapy

L. Yan, Wu, M., Ba, N., Shi, G., Wang, L., Zhang, H., Yan, L., Wu, M., Ba, N., Shi, G., Wang, L., and Zhang, H., “Changes in T-lymphocytes in lung cancer patients after hyperthermic intraperitoneal chemotherapy or radiotherapy”, vol. 15, p. -, 2016.

We investigated dynamic changes in T-lymphocyte subsets after hyperthermic intraperitoneal chemotherapy (HIPEC) or radiotherapy using flow cytometry. A total of 1423 lung cancer patients admitted to our hospital between October 2012 and July 2015 were enrolled, and age-matched healthy individuals served as controls. Peripheral blood mononuclear cells (PBMCs) were purified using standard Ficoll density gradient centrifugation, based on which CD3+, CD4+, and CD8+ T-cells were isolated. A surface marker was identified by flow cytometry.

MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation

Y. Yang, Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., and Liu, H., “MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation”, vol. 15, p. -, 2016.

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource Integrated Database for papers on C677T and A1298C and susceptibility to lung cancer was performed. The STATA software (Version 13.0) was used for statistical analysis.

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