Lung cancer

Combined detection of p53, p16, Rb, and EGFR mutations in lung cancer by suspension microarray

Y. Ye, Wang, D., Su, C., Rong, T., and Guo, A., Combined detection of p53, p16, Rb, and EGFR mutations in lung cancer by suspension microarray, vol. 8, pp. 1509-1518, 2009.

Mutations of some contributing factors (p53, p16, Rb, and EGFR) are believed to affect diagnosis and drug resistance of lung cancer. We evaluated the efficacy of a multimarker panel for molecular diagnosis of lung cancer, using a high-throughput suspension microarray. One hundred and twenty-five lung cancer specimens and 30 tumor-free lung tissue samples were assayed by multiplex polymerase chain reaction with specific probes designed to detect hot-spot mutations in p53, p16, Rb, and EGFR.

Pages

Subscribe to Lung cancer