Lupus nephritis

Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus

J. R. Lin, Qin, H. H., Wang, Y., Liang, J., Xu, J. H., Lin, J. R., Qin, H. H., Wang, Y., Liang, J., and Xu, J. H., Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus, vol. 15, p. -, 2016.

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore the genetic basis underlying the pathogenesis of SLE. In this study, we investigated the potential correlation between the functional IL19 SNP rs2243188 and SLE.

Relationship between urinary protein changes in lupus nephritis and renal pathology

M. Li, Gao, W. J., Ma, J. J., Zhu, Y., and Li, X. F., Relationship between urinary protein changes in lupus nephritis and renal pathology, vol. 14, pp. 8352-8358, 2015.

This study investigated the relationship between urinary protein excretion in lupus nephritis New Zealand black mice and renal pathology. A total of 328 lupus nephritis New Zealand black mice were established by a backcross hybridization method, and renal pathology was determined. The urinary protein excretion of the backcross mice over 24 h was compared and analyzed. Urinary protein excretion over 24 h differed significantly across different pathological types (1.9, 2.4, 2.9 and 4.9 g in types II, III, IV, and V, respectively) in the backcross mice (P

Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis

X. F. Ma, Xu, F. L., Gao, L. F., Wang, Y. X., and Pan, Z. B., Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis, vol. 14, pp. 10999-11005, 2015.

We investigated the effect of age on the expression of immune molecules [ANA, C4, double stranded DNA (dsDNA), CD16/32, CD19, CD3, and CD64], urine protein, and pathology in mice with chronic graft-versus-host disease (cGVHD) lupus nephritis (LN), and their relationship with reactivity index score. Mouse models of cGVHD LN were established, and mice were randomly divided into four aged-based groups of nine mice each. Serum levels of ANA, C4, and dsDNA were determined, the urine protein levels were assessed, and expression levels of CD16/32, CD19, CD3, and CD64 were measured.

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