Male infertility

Chromosome 7 translocation breakpoints in male carriers: clinical features and implications for genetic counseling

R. X. Wang, Zhang, H. G., Pan, Y., Zhu, J. H., Yue, F. G., Xue, L. T., Liu, R. Z., Wang, R. X., Zhang, H. G., Pan, Y., Zhu, J. H., Yue, F. G., Xue, L. T., and Liu, R. Z., “Chromosome 7 translocation breakpoints in male carriers: clinical features and implications for genetic counseling”, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis

Y. Yang, Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., Liu, H., Yang, Y., Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., Liu, H., Yang, Y., Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., and Liu, H., “Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis”, vol. 15, p. -, 2016.

Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of PubMed, EMBASE, the Cochrane Library, the Web of Science, and the China Knowledge Resource Integrated Database for papers on MTHFR gene C677T and A1298C polymorphisms and male infertility risk.

Investigation of AZF microdeletions in patients with Klinefelter syndrome

L. X. Li, Dai, H. Y., Ding, X. P., Zhang, Y. P., Zhang, X. H., Ren, H. Y., and Chen, Z. Y., “Investigation of AZF microdeletions in patients with Klinefelter syndrome”, vol. 14, pp. 15140-15147, 2015.

We investigated azoospermia region microdeletions in male infertility patients with Klinefelter syndrome (KFS), as well as the association between azoospermia symptoms in patients with KFS and Y chromosome microdeletion polymorphisms. A total of 111 cases with male infertility confirmed to have KFS (47, XXY) and 94 fertile men were included in this study. Peripheral blood was drawn and DNA was extracted from these samples. Multiplex polymerase chain reaction was performed to screen the partial deletions of 25 sequence-tagged sites on the Y chromosome.

Correlation between chromosomal polymorphisms and male infertility in a Northeast Chinese population

L. L. Li, Peng, D., Wang, R. X., Zhu, H. B., Wang, W. J., and Liu, R. Z., “Correlation between chromosomal polymorphisms and male infertility in a Northeast Chinese population”, vol. 14, pp. 15435-15443, 2015.

The aim of this study was to evaluate the correlation between chromosomal polymorphisms and male infertility. The patients were diagnosed with azoospermia or oligospermiaby a semen analysis. Chromosomal analysis was performed on peripheral blood lymphocytes obtained from the patients, with standard G-banding and C-banding. Y chromosome microdeletions were detected by multiplex polymerase chain reaction (PCR) amplification. The parents of 35 polymorphic probands were also subjected to chromosomal analysis, and their detailed reproductive histories were surveyed.

Association between RsaI polymorphism in estrogen receptor β gene and male infertility

B. M. Bordin and Moura, K. K. V. O., “Association between RsaI polymorphism in estrogen receptor β gene and male infertility”, vol. 14, pp. 10954-10960, 2015.

The estrogen receptor β (ERβ) gene plays an important role in the regulation of fertility in both males and females. The RsaI polymorphism in ERβis associated with male infertility in Caucasian patients. The aim of this study was to investigate the frequency of this polymorphism in the etiology of idiopathic male infertility and its correlation with smoking habits. We analyzed 287 Brazilian men, including 161 infertile and 126 fertile men, to evaluate the association between the RsaI polymorphism and male infertility.

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