MAPKs signaling pathway

JNK pathway and relative transcriptional factor were involved in ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells

X. Liu, Sun, Y., Yue, L., Li, S., Qi, X., Zhao, H., Yang, Y., Zhang, C., Yu, H., Liu, X., Sun, Y., Yue, L., Li, S., Qi, X., Zhao, H., Yang, Y., Zhang, C., and Yu, H., JNK pathway and relative transcriptional factor were involved in ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells, vol. 15, p. -, 2016.

Ginsenoside Rh2 has been shown to have an anti-tumor effect on a wide range of cancers. A previous study has shown that ginsenoside Rh2 can inhibit the proliferation of the human lung adenocarcinoma A549 cell line in a dose-dependent manner by activating caspase-8/3 activity to promote apoptosis. However, the association of the JNK signaling pathways and transcription factors with ginsenoside Rh2 in the suppression of non-small cell lung cancer has not yet been reported.

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