MDR1 (ABCB1)

Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility

S. E. Aydos, Karadağ, A., Özkan, T., Altınok, B., Bunsuz, M., Heidargholizadeh, S., Aydos, K., and Sunguroĝlu, A., Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility, vol. 14, pp. 6330-6339, 2015.

Infertility affects 1 in 6 couples and approximately 1 in 25 men. Male factor infertility is a major cause of spermatogenic anomalies, the causes of which are largely unknown. Impaired repro­ductive functions in men might result from physiological, genetic, and/or environmental factors such as xenobiotics. The multi-drug re­sistance1 (MDR1) gene encodes a P-glycoprotein which has a role in the active transport of various substrates providing protection of somatic cells from potentially toxic substances, including xenobi­otics.

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