Melatonin

Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon

E. B. Machado, Souza, B. B., Guimarães, R. C., Azevedo, J. S. N., Gonçalves, E. C., Ribeiro, H. F. L., Filho, S. T. Rolim, E. Filho, S., Machado, E. B., Souza, B. B., Guimarães, R. C., Azevedo, J. S. N., Gonçalves, E. C., Ribeiro, H. F. L., Filho, S. T. Rolim, and E. Filho, S., Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon, vol. 15, p. -, 2016.

Buffalo farming in Brazil is increasing, as is the challenge of identifying molecular markers that will improve productivity. Therefore, the aim of this study was to analyze single nucleotide polymorphisms of the receptor gene for the hormone melatonin in buffaloes from northern Brazil by polymerase chain reactions (PCRs) and restriction fragment length polymorphism assays. The PCR products exhibited a cutting point for HpaI at the 318th position of the gene, indicating a transition substitution (T↔C).

Effect of melatonin on oncosis of myocardial cells in the myocardial ischemia/reperfusion injury rat and the role of the mitochondrial permeability transition pore

L. F. Liu, Qian, Z. H., Qin, Q., Shi, M., Zhang, H., Tao, X. M., and Zhu, W. P., Effect of melatonin on oncosis of myocardial cells in the myocardial ischemia/reperfusion injury rat and the role of the mitochondrial permeability transition pore, vol. 14, pp. 7481-7489, 2015.

We aimed to evaluate the effect of melatonin on myo­cardial cell oncosis in the myocardial ischemia/reperfusion injury rat, and the role of the mitochondrial permeability transition pore (MPTP) therein. Sprague Dawley rats (N = 60) were randomly divided into five groups of 12 rats each: control, ischemia/reperfusion (I/R), melatonin treatment (MT), melatonin treatment + atractyloside (MT+ATR), and atractyloside (ATR). We prepared the myocardial ischemia/reperfusion model by reperfusion after the left anterior descending coronary artery was ligated for 30 min.

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