Mesenchymal stem cells

Transplantation of erythropoietin gene-transfected umbilical cord mesenchymal stem cells as a treatment for limb ischemia in rats

J. P. Li, Wang, D. W., and Song, Q. H., Transplantation of erythropoietin gene-transfected umbilical cord mesenchymal stem cells as a treatment for limb ischemia in rats, vol. 14, pp. 19005-19015, 2015.

The aim of this study was to investigate the mechanisms of erythropoietin (EPO)-transfected umbilical cord mesenchymal stem cells (UC-MSCs) in the treatment of rats with ischemic limb and provide a theoretical basis for optimization of UC-MSC transplantation. Sixty SD rats were randomly divided into four groups: ischemia control group, EPO treatment group, UC-MSCs treatment group, EPO gene transfected UC-MSC treatment groups (15 rats in each group). The left femoral hind artery and its branches were ligated to develop hind limb ischemia in male SD rats.

Synergistic effect of BMP9 and TGF-β in the proliferation and differentiation of osteoblasts

X. L. Li, Liu, Y. B., Ma, E. G., Shen, W. X., Li, H., and Zhang, Y. N., Synergistic effect of BMP9 and TGF-β in the proliferation and differentiation of osteoblasts, vol. 14, pp. 7605-7615, 2015.

We investigated the synergistic effect of bone morphoge­netic protein 9 (BMP9) and transforming growth factor (TGF)-b in the transformation of mesenchymal stem cells into osteoblasts. We evalu­ated the effect of BMP9 and TGF-b on the induction of osteoblast for­mation. Mitogen-activated protein kinase (MAPK) pathway-related pro­teins such as p38, extracellular receptor kinase 1/2, and c-Jun N-terminal kinase (JNK) were analyzed. The interactions between TGF-Smad and BMP-MAPK were also studied.

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