Mesenchymal stem cells

Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells.

H. - J. Cao, Wang, M. - D., Li, S. - G., Zhu, L., and Zheng, J. - H., “Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells.”, Genet Mol Res, vol. 16, no. 1, 2017.

Immunomodulatory and neuroprotective effect of cryopreserved allogeneic mesenchymal stem cells on spinal cord injury in rats.

I. R. Rosado, Carvalho, P. H., Alves, E. G. L., Tagushi, T. M., Carvalho, J. L., Silva, J. F., Lavor, M. S. L., Oliveira, K. M., Serakides, R., Goes, A. M., and Melo, E. G., “Immunomodulatory and neuroprotective effect of cryopreserved allogeneic mesenchymal stem cells on spinal cord injury in rats.”, Genet Mol Res, vol. 16, no. 1, 2017.

Rehmannia glutinosa oligosaccharide induces differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells

X. H. Wang, Du, H. W., Guo, X. H., Wang, S. W., Zhou, R. B., Li, Y., Li, Z. B., Zhao, Y. S., and Zhu, Q. L., “Rehmannia glutinosa oligosaccharide induces differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells”, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Increased miR-155-5p expression in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA expression profile by microarray

R. X. Hou, Liu, R. F., Zhao, X. C., Jia, Y. R., An, P., Hao, Z. P., Li, J. Q., Li, X. H., Yin, G. H., Zhang, K. M., Hou, R. X., Liu, R. F., Zhao, X. C., Jia, Y. R., An, P., Hao, Z. P., Li, J. Q., Li, X. H., Yin, G. H., and Zhang, K. M., “Increased miR-155-5p expression in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA expression profile by microarray”, vol. 15, p. -, 2016.

Mesenchymal stem cells (MSCs) have pleiotropic immuno-modulatory effects and pro-angiogenic ability, leading to the presumption that MSCs may be involved in the pathogenesis of many inflammatory or autoimmune disorders, including psoriasis. In a previous study, we reported the specific gene expression profile of dermal MSCs from psoriasis.

Identification of long non-coding RNA involved in osteogenic differentiation from mesenchymal stem cells using RNA-Seq data

W. Q. Song, Gu, W. Q., Qian, Y. B., Ma, X., Mao, Y. J., and Liu, W. J., “Identification of long non-coding RNA involved in osteogenic differentiation from mesenchymal stem cells using RNA-Seq data”, vol. 14, pp. 18268-18279, 2015.

The aim of this study was to identify long non-coding RNA (lncRNA) associated with osteogenic differentiation from mesenchymal stem cells (MSCs) using high-throughput RNA sequencing (RNA-Seq) data. RNA-Seq dataset was obtained from the European Bioinformatics Institute (accession No. PRJEB4496), including two replicates each for immortalized mesenchymal stem cells iMSC#3 cultured in growth medium (GM) and differentiation medium (DM) for 28 days. The clean reads were aligned to a hg19 reference genome by Tophat and assembled by Cufflinks to identify the known and novel transcripts.

Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells

J. Y. Zhang and Li, L. C., “Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells”, vol. 14, pp. 18210-18217, 2015.

Past studies have revealed the critical role of runt-related transcription factor 2 (RUNX2) in the proliferation and differentiation of mesenchymal stem cells (MSCs). This study therefore aimed to investigate the expression profile of the RUNX2 gene in human bone marrow MSCs and its biological characteristics. Bone marrow MSCs were separated from 12 patients who had received hip joint replacement surgery.

Synergistic effect of BMP9 and TGF-β in the proliferation and differentiation of osteoblasts

X. L. Li, Liu, Y. B., Ma, E. G., Shen, W. X., Li, H., and Zhang, Y. N., “Synergistic effect of BMP9 and TGF-β in the proliferation and differentiation of osteoblasts”, vol. 14, pp. 7605-7615, 2015.

We investigated the synergistic effect of bone morphoge­netic protein 9 (BMP9) and transforming growth factor (TGF)-b in the transformation of mesenchymal stem cells into osteoblasts. We evalu­ated the effect of BMP9 and TGF-b on the induction of osteoblast for­mation. Mitogen-activated protein kinase (MAPK) pathway-related pro­teins such as p38, extracellular receptor kinase 1/2, and c-Jun N-terminal kinase (JNK) were analyzed. The interactions between TGF-Smad and BMP-MAPK were also studied.

Treatment of silicosis with hepatocyte growth factor-modified autologous bone marrow stromal cells: a non-randomized study with follow-up

W. W. Liu, Wang, H. X., Yu, W., Bi, X. Y., Chen, J. Y., Chen, L. Z., Ding, L., Han, D. M., Guo, Z. K., and Lei, Y. X., “Treatment of silicosis with hepatocyte growth factor-modified autologous bone marrow stromal cells: a non-randomized study with follow-up”, vol. 14, pp. 10672-10681, 2015.

Pulmonary silicosis is an irreversible and untreatable disease that is characterized by interstitial lesions and perpetual fibrosis in the lungs. This study was performed to determine whether mesenchymal stem cells (MSCs) and hepatocyte growth factor (HGF) could exhibit therapeutic effects on human silicosis. This non-randomized uncontrolled trial comprised four patients with pulmonary silicosis who had developed lung fibrosis and received autologous bone marrow MSCs previously transfected by a vector containing human HGF cDNA (MSCs/HGF).

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