Meta-analysis

Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis

Y. Liu, Song, X. L., Zhang, G. L., Peng, A. M., Fu, P. F., Li, P., Tan, M., Li, X., Li, M., and Wang, C. H., “Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis”, vol. 14, pp. 163-169, 2015.

The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized the Q-test and I2 test to determine heterogeneity between each study.

TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis

H. G. Wang, Yang, J., Han, H., Xu, F., Bian, Y., Zhang, H., and Wang, J. L., “TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis”, vol. 14, pp. 563-573, 2015.

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE).

Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis

B. W. Yu, Zhang, L. Q., Teng, X. L., Zhang, Y., Zou, L. B., and Ying, H. Y., “Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis”, vol. 14, pp. 1076-1084, 2015.

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T＞C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and EMBASE databases up to April 2014. We estimated the pooled odds ratio with its 95% confidence interval to assess the association using a fixed or random-effects model.

Meta-analysis of constitutive QTLs for disease resistance in maize and its synteny conservation in the rice genome

L. Zhao, Liu, H. J., Zhang, C. X., Wang, Q. Y., and Li, X. H., “Meta-analysis of constitutive QTLs for disease resistance in maize and its synteny conservation in the rice genome”, vol. 14, pp. 961-970, 2015.

We collected data regarding 340 disease resistance quantitative trait loci (QTLs) from the maize genomic database (MaizeGDB). We constructed an integrated linkage map and analyzed this map by using the BioMercator 2.1 software with IBM2 2008 Neighbors genetic linkage map as a reference. We used a meta-analysis method to identify five “consensus” synthetic resistance QTLs located on maize chromosomes 1, 3, 6, and 10, with map intervals of 5.14, 9.00, 28.50, 1.73, and 33.34 cM, respectively.

Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer’s disease in the Chinese population: a meta-analysis of case-control studies

L. Yang, Zhou, H. - H., Ye, Y. - F., Fan, X. - W., Wang, Y. - J., and Meng, Y., “Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer’s disease in the Chinese population: a meta-analysis of case-control studies”, vol. 14, pp. 1017-1024, 2015.

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to obtain summary estimates regarding their associations with AD.

Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis

W. Zheng, Wang, L., Su, X., and Hu, X. F., “Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis”, vol. 14, pp. 989-999, 2015.

In this study, we evaluated the associations between the V4 (rs2787094 G>C) polymorphism in a disintegrin and metalloproteinase domain 33 (ADAM33) gene and asthma risk. We searched Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 2013, without language restrictions. Meta-analysis was performed using the STATA 12.0 software. Crude odds ratios and 95% confidence intervals were calculated. Eight case-control studies were included, with a total of 2128 asthma patients and 3134 healthy controls.

Relationship between vitamin D (1,25-dihydroxyvitamin D3) receptor gene polymorphisms and primary biliary cirrhosis risk: a meta-analysis

F. Fang, Wang, J., Pan, J., Su, G. H., Xu, L. X., and Li, G., “Relationship between vitamin D (1,25-dihydroxyvitamin D3) receptor gene polymorphisms and primary biliary cirrhosis risk: a meta-analysis”, vol. 14, pp. 981-988, 2015.

The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary cirrhosis (PBC) risk. We conducted an overall meta-analysis and subgroup meta-analysis based on ethnicity that included a total of 6 eligible studies (672 cases and 1148 controls).

Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis

D. W. Suo, Hu, Q., Chen, J., Sun, Q. H., and Guo, H., “Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis”, vol. 14, pp. 1566-1579, 2015.

Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the TNF-β C804A polymorphism to MI risk.

Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis

H. Liu, Ma, H. F., and Chen, Y. K., “Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis”, vol. 14, pp. 1385-1392, 2015.

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a random-effect model to pool the odds ratios (ORs) and 95% confidence intervals (CIs).

Androgen receptor gene CAG repeat polymorphism and risk of isolated hypospadias: results from a meta-analysis

G. Huang, Shan, W., Zeng, L., and Huang, L., “Androgen receptor gene CAG repeat polymorphism and risk of isolated hypospadias: results from a meta-analysis”, vol. 14, pp. 1580-1588, 2015.

Studies investigating the association between the CAG repeat polymorphism and the risk of isolated hypospadias have reported conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, CNKI, and Wanfang databases. Weighted mean difference and 95% confidence intervals for the CAG repeat polymorphism and isolated hypospadias were calculated using a random-effects model.

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