Meta-analysis

Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis

T. L. Jia, Wu, H. J., Wang, H. B., Ma, W. B., and Xing, B., “Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis”, vol. 14, pp. 12577-12584, 2015.

Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the PubMed, Web of Science, Cochrane Library, and EMBASE databases published through June 1, 2014. A total of 11 studies for ERCC2 rs13181 were selected; these included 3456 glioma cases and 4957 controls.

Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis

Y. Du, Gao, L., Zhang, K., and Wang, J., “Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis”, vol. 14, pp. 13236-13246, 2015.

The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out to determine whether this SNP is associated with cancer risk. However, the results are inconsistent due to small sample sizes of individual studies and limited statistical power.

Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis

R. Zeng, Wang, Q. P., Fang, M. X., Zhuang, J., and Fan, R. X., “Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis”, vol. 14, pp. 12984-12992, 2015.

The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved from PubMed. Pooled odd’s ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effect models.

Implicating the H63D polymorphism in the HFE gene in increased incidence of solid cancers: a meta-analysis

L. L. Shen, Gu, D. Y., Zhao, T. T., Tang, C. J., Xu, Y., and Chen, J. F., “Implicating the H63D polymorphism in the HFE gene in increased incidence of solid cancers: a meta-analysis”, vol. 14, pp. 13735-13745, 2015.

A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors. However, the clinical outcomes were inconsistent. Therefore, this meta-analysis was conducted to summarize the effect of the H63D variant on the incidence of solid tumor. PubMed and EMBASE databases were searched for articles associating the HFE H63D polymorphism with cancer risk.

Relationship between serum leptin levels and non-small cell lung carcinoma: a meta-analysis

J. Du, Han, J. C., Zhang, Y. J., Qi, G. B., Zhang, Y., and Li, H. B., “Relationship between serum leptin levels and non-small cell lung carcinoma: a meta-analysis”, vol. 14, pp. 13699-13708, 2015.

In this study, we analyzed the association between serum leptin levels and non-small cell lung carcinoma (NSCLC). By examining English and Chinese databases, we identified potential relevant studies for statistical analysis. Human-associated case-control studies evaluating the association between serum leptin levels and NSCLC according to the random-effect model were retrieved and extracted data were statistically analyzed.

Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis

J. Y. Ban, Shin, J. I., and Oh, C. - H., “Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis”, vol. 14, pp. 13906-13914, 2015.

The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched PubMed, Medline, and Korean Studies Information Service System databases and identified 29 case-control studies, containing data of 25,324 individuals, for this meta-analysis.

ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk

N. Jiang, Yang, G., and Peng, C. L., “ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk”, vol. 14, pp. 13932-13944, 2015.

The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scientific literature databases, which was complemented by manual searches. Data from studies selected were analyzed using the Comprehensive Meta-analysis 2.0 software.

Association between MYC rs9642880[T] allele and bladder cancer risk: a meta-analysis

Y. Zhao, Qi, J. G., Yang, N., Lin, Y. L., Liang, J., and Zhu, X., “Association between MYC rs9642880[T] allele and bladder cancer risk: a meta-analysis”, vol. 14, pp. 14745-14751, 2015.

A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive. To assess the association between rs9642880[T] allele and bladder cancer risk, we performed this meta-analysis including 18 case-control studies and involving 23,084 cases and 97,164 controls. Electronic searches for publications were conducted to determine the association between this variant and prostate cancer in several databases.

Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis

W. G. Hu, Pan, R. J., Cai, W., Wang, Z. T., and Zhu, Z. G., “Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis”, vol. 14, pp. 14670-14679, 2015.

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. This case-control study involved 448 patients clinically diagnosed with gastric cancer and 372 cancer-free control individuals from China.

Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis

Y. H. Lee and Song, G. G., “Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis”, vol. 14, pp. 14396-14405, 2015.

The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibil­ity to psoriasis. Meta-analyses were conducted to examine the asso­ciations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and reces­sive, dominant, and additive models. Seven studies on VEGF polymor­phisms and psoriasis involving 1956 subjects (psoriasis patients 665, controls 1291) were included in this meta-analysis.

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