Meta-analysis

Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility

L. Z. Zhang, Li, Y. S., and Liu, H. Z., Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility, vol. 14, pp. 14831-14839, 2015.

Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 T241M polymorphism and CRC risk. The PubMed and Embase databases were searched for relevant studies investigating the relationship between the XRCC3 T241M polymorphism and CRC risk.

Serum levels of S-100β correlate with the clinical status and severity of hypoxic-ischemic encephalopathy in neonates

L. H. Shi, Zhou, Y., Guo, M. F., Liu, J. S., Li, C. X., Wang, G. F., Liu, W., and Tian, L., Serum levels of S-100β correlate with the clinical status and severity of hypoxic-ischemic encephalopathy in neonates, vol. 14, pp. 14760-14771, 2015.

The clinical significance of serum S-100β levels in neonates with hypoxic-ischemic encephalopathy (HIE), as a reference index to assess HIE severity, was evaluated in this study. On the basis of our strict inclusion and exclusion criteria, relevant high-quality case-control studies reporting the association between HIE and S-100β protein were selected from electronic database searches. The STATA version 12.0 software was used for the statistical analyses.

Correlation between non-metastatic protein 23 expression and clinicopathological features of colorectal cancer in Asians

J. W. Fu and Chu, X. Q., Correlation between non-metastatic protein 23 expression and clinicopathological features of colorectal cancer in Asians, vol. 14, pp. 15597-15608, 2015.

The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians. English and Chinese language-based electronic databases (e.g., PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wanfang databases, China National Knowledge Infrastructure, VIP databases) were searched using search terms to identify published studies relevant to NM23 and CRC with immunohistochemistry.

A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections

C. Lin, Ye, R., and Xia, Y. L., A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections, vol. 14, pp. 15634-15641, 2015.

Novel coronavirus (nCoV) belongs to the Coronaviridae family, which includes the virus that causes SARS, or severe acute respiratory syndrome. However, infection source, transmission route, and host of nCoV have not yet been thoroughly characterized. In some cases, nCoV presented a limited person-to-person transmission. Therefore, early diagnosis of nCoV may be of importance for reducing the spread of disease in public. Methods for nCoV diagnosis involve smear dyeing inspection, culture identification, and real-time PCR detection, all of which are proved highly effective.

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

X. Zhang, Zheng, C., Zhou, Z. H., Li, M., Gao, Y. T., Jin, S. G., Sun, X. H., and Gao, Y. Q., Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis, vol. 14, pp. 15553-15563, 2015.

The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out using the PubMed and Google Scholar databases.

Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis

F. Fang, Pan, J., Su, G. H., Xu, L. X., Li, G., Li, Z. H., Zhao, H., and Wang, J., Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis, vol. 14, pp. 15267-15275, 2015.

Numerous studies have focused on the relationship be­tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal­ysis to more precisely estimate this association. Relevant publications were searched in several widely used databases and 9 eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association.

Elevated serum homocysteine level in the development of diabetic peripheral neuropathy

L. Q. Zheng, Zhang, H. L., Guan, Z. H., Hu, M. Y., Zhang, T., and Ge, S. J., Elevated serum homocysteine level in the development of diabetic peripheral neuropathy, vol. 14, pp. 15365-15375, 2015.

The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DPN. We screened the Embase, Ovid, PubMed, Web of Science, Wangfang, and China National Knowledge Infrastructure databases.

Relationship between the HLA-G 14bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis

S. K. Kim, Jeong, K. H., Kang, I. J., Chung, J. H., Shin, M. K., and Lee, M. H., Relationship between the HLA-G 14bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis, vol. 14, pp. 15839-15847, 2015.

Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and EMBASE databases was conducted to identify eligible studies investigating the association of the HLA-G 14-bp INS/DEL polymorphism with AID.

Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis

J. Cai, Yang, M. Y., Hou, N., and Li, X., Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis, vol. 14, pp. 16102-16112, 2015.

We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database were searched for all case-control studies on the relationship between the TNF-α 308G/A polymorphism and susceptibility to urogenital cancer between January 1994 and January 2015.

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

B. F. Chen, Wang, R., Chen, Y. J., Zhu, Y., Ding, L., and Wen, Y. F., Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis, vol. 14, pp. 15859-15868, 2015.

Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association between HLA‑DRB1 alleles and TB susceptibility through a systematic research. Data from eligible fifteen studies were included in the meta-analyses.

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