Meta-analysis

Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis

J. Cai, Yang, M. Y., Hou, N., and Li, X., Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis, vol. 14, pp. 16102-16112, 2015.

We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database were searched for all case-control studies on the relationship between the TNF-α 308G/A polymorphism and susceptibility to urogenital cancer between January 1994 and January 2015.

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

B. F. Chen, Wang, R., Chen, Y. J., Zhu, Y., Ding, L., and Wen, Y. F., Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis, vol. 14, pp. 15859-15868, 2015.

Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association between HLA‑DRB1 alleles and TB susceptibility through a systematic research. Data from eligible fifteen studies were included in the meta-analyses.

Lack of association between the aryl hydrocarbon receptor rs2066853 polymorphism and breast cancer: A meta-analysis on Ahr polymorphism and breast cancer

Y. Li, Qin, H. Z., Song, Q., Wu, X. D., and Zhu, J. H., Lack of association between the aryl hydrocarbon receptor rs2066853 polymorphism and breast cancer: A meta-analysis on Ahr polymorphism and breast cancer, vol. 14, pp. 16162-16168, 2015.

Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer. The protocol was approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Florida (America NIH Publication No. 86-231985 Revision).

Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis

M. Zhang, Zhao, L. J., Liang, W. Q., and Mao, Z. P., Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis, vol. 14, pp. 16562-16576, 2015.

Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search for relevant studies up to August 4, 2014 was conducted in databases and other sources. Statistical analysis was conducted using STATA 12.0.

Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer

W. Pan and Liao, H., Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer, vol. 14, pp. 16813-16818, 2015.

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, and WanFang Data. The literature was screened based on inclusion and exclusion criteria.

Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis

J. W. Gao, Zhang, K. F., Lu, J. S., and Su, T., Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis, vol. 14, pp. 17068-17078, 2015.

Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching the following databases: PubMed, Embase, CINAHL, Science Citation Index database, the Cochrane Library, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal.

Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility

X. H. Liu, Xie, C. G., An, Y., Zhang, X. X., and Wu, W. B., Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility, vol. 14, pp. 16856-16862, 2015.

Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for evidence-based medicinal treatment of T2DM.

Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk

G. Nie, Qi, J. H., Huang, C. W., Yang, T., Shi, N., and Chen, Y. J., Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk, vol. 14, pp. 17296-17304, 2015.

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the association between TNF-α-308G/A polymorphism and vitiligo risk were retrieved from PubMed and EmBase databases.

Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis

Z. Wang, Li, M., Li, L., Sun, H., and Lin, X. Y., Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis, vol. 14, pp. 17262-17272, 2015.

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, including EMBase, Web of Science, and PubMed. The extracted studies were selected for the meta-analysis based on the inclusion and exclusion criteria.

Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis

J. X. Liang, Gao, W., Liang, Y., and Zhou, X. M., Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis, vol. 14, pp. 17219-17227, 2015.

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results.

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