Meta-analysis

Elevated expression of CXCR4 and correlation with clinicopathological features and prognosis of non-small cell lung cancer patients: a meta-analysis

H. Wang, Xie, F., Hu, Z., and Chen, L., Elevated expression of CXCR4 and correlation with clinicopathological features and prognosis of non-small cell lung cancer patients: a meta-analysis, vol. 14, pp. 17893-17903, 2015.

The specific correlation between CXCR4 expression and survival in non-small cell lung cancer (NSCLC) has been investigated independently; however, these have yielded inconsistent results. Therefore, we examined the exact relationship between CXCR4 expression and NSCLC in this meta-analysis. The bibliographic databases in English and Chinese were carefully searched and data regarding the prognostic value of CXCR4 and its association with pathological parameters of NSCLC were collected. Pooled odds ratios (OR) with 95% confidence interval (CI) were applied.

AGER genetic polymorphisms increase risks of breast and lung cancers

N. C. Yin, Lang, X. P., Wang, X. D., and Liu, W., AGER genetic polymorphisms increase risks of breast and lung cancers, vol. 14, pp. 17776-17787, 2015.

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases.

Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis

M. L. Zhi, Liu, Z. J., Yi, X. Y., Zhang, L. J., and Bao, Y. X., Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis, vol. 14, pp. 18018-18025, 2015.

Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based miR-29a for CRC. We performed a systematic review of studies published over the past two decades to investigate the diagnostic performance of serum miR-29a for the diagnosis of CRC.

Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis

Y. - F. Yu, Han, Z. - G., Guo, W. - B., Zhang, G. - J., Yang, J. - K., Wu, F. - L., Ou, Q. - Y., Li, Y. - H., Cai, X. - Y., Zhan, Z. - N., Chen, J. - H., Xie, W. - L., Tang, L., and Liu, C. - D., Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis, vol. 14, pp. 18945-18957, 2015.

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort studies were quantitatively analyzed to evaluate IL-10 promoter gene polymorphisms and NPC risk.

Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis

B. Zhu, Yin, L., and Zhang, J. Y., Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis, vol. 14, pp. 18851-18858, 2015.

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 control subjects. A systematic literature search (for articles published up to September 2014) utilizing Google Scholar and PubMed was conducted.

Correlation of increased MALAT1 expression with pathological features and prognosis in cancer patients: a meta-analysis

X. S. Shi, Li, J., Yang, R. H., Zhao, G. R., Zhou, H. P., Zeng, W. X., and Zhou, M., Correlation of increased MALAT1 expression with pathological features and prognosis in cancer patients: a meta-analysis, vol. 14, pp. 18808-18819, 2015.

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a potential cancer biomarker, yet the mechanism by which it influences the development of cancer remains unknown. In this study, we aimed to correlate MALAT1 expression with pathological features and prognosis in cancer patients. Several databases were searched using combinations of keywords relating to MALAT1 and cancer. After selection of relevant cohort studies according to strict criteria, a meta-analysis was conducted.

Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases

Y. Li, Zhu, J., and Ding, J. Q., Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases, vol. 14, pp. 18662-18674, 2015.

This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of high-quality patients-control studies.

Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis

L. L. Zhang, Wang, Y. Q., Fu, B., Zhao, S. L., and Kui, Y., Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis, vol. 14, pp. 18503-18514, 2015.

We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and 5016 controls in 12 case-control studies were included in this meta-analysis.

Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis

H. S. Zhu, Zhang, J. F., Zhou, J. D., Zhang, M. J., and Hu, H. X., Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis, vol. 14, pp. 19329-19341, 2015.

Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independently by two investigators. Pooled odds ratios (ORs) and 95% confidence intervals for 8q24 rs6983267 T/G and PCa were calculated using a fixed-effect model (the Mantel-Haenszel method).

Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis

Q. B. Yu, Li, H. M., Li, L. L., Wang, S. Y., and Wu, Y. B., Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis, vol. 14, pp. 19016-19027, 2015.

This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB). The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used.

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