Meta-analysis

Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

Y. H. Lee and Song, G. G., Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis, vol. 14, pp. 9361-9369, 2015.

The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms.

Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis

D. Y. Liu, Liang, H. C., and Xiao, X. M., Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis, vol. 14, pp. 9821-9828, 2015.

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and 2919 controls.

Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis

Y. L. Wang, Kong, H., Xie, W. P., and Wang, H., Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis, vol. 14, pp. 10774-10785, 2015.

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene polymorphism and COPD. After qualitative evaluation, randomized controlled trials were pooled using either a fixed- or a random-effect model depending upon the degree of heterogeneity.

COL1A1 gene -1997G/T polymorphism and risk of osteoporosis in postmenopausal women: a meta-analysis

K. H. Yu, Tang, J., Dai, C. Q., Yu, Y., and Hong, J. J., COL1A1 gene -1997G/T polymorphism and risk of osteoporosis in postmenopausal women: a meta-analysis, vol. 14, pp. 10991-10998, 2015.

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the PubMed and Embase databases up to September 2014. We estimated the pooled odds ratios with their 95% confidence intervals to assess the associations using fixed- or random-effect models.

Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis

Z. Z. Li, Qin, W. Z., Li, L., Wu, Q., and Wang, Y. J., Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis, vol. 14, pp. 11672-11680, 2015.

Current methods for diagnosing tuberculous pleurisy are poor. Some studies have explored the diagnostic value of a pleural effusion enzyme-linked immunospot (ELISPOT) assay, but its accuracy remains controversial. Therefore, we performed a meta-analysis of the existing evidence on the ability of the ELISPOT assay to diagnose tuberculous pleurisy. We systematically searched PubMed, Google Scholar, and EMBASE databases for studies measuring the sensitivity, specificity, and other measures of accuracy of the pleural effusion ELISPOT assay for diagnosis of tuberculous pleurisy.

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