Meta-analysis

T174M polymorphism in the angiotensinogen gene and risk of myocardial infarction: a meta-analysis

P. Y. Hu, Wang, Y. W., Pang, X. H., and Wang, H. W., T174M polymorphism in the angiotensinogen gene and risk of myocardial infarction: a meta-analysis, vol. 14, pp. 3767-3774, 2015.

Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensive search was conducted to identify all published articles regarding the association between the AGT gene T174M polymorphism and MI risk from different databases.

Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis

J. H. Qi, Shi, N., Chen, Y. J., and Nie, G., Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis, vol. 14, pp. 3869-3876, 2015.

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T polymorphism and psoriasis risk were retrieved from the PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases.

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk

R. Zhu, Bi, L. Q., Kong, H., Tilley, S. L., Wang, H., and Xie, W. P., Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk, vol. 14, pp. 3590-3600, 2015.

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval.

Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma

J. H. Zhong, Li, L. Q., Mo, X. S., Gong, W. F., Ma, L., Chen, J., and You, X. - M., Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma, vol. 14, pp. 4133-4141, 2015.

Carcinogenesis of breast carcinoma is very complicated. Previous studies have suggested conflicting results regarding the association between Tyr113His and His139Arg microsomal epoxide hydrolase (mEH) gene polymorphisms and risk of breast carcinoma. We conducted a meta-analysis to examine the relationship between these polymorphisms and breast carcinoma risk. We searched the PubMed, EMBASE, and Google Scholar databases to identify relevant studies.

Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis

G. Q. Zhou, Meng, H., Wang, J. R., Sun, F. X., Wang, X. J., Wang, R. B., and Wang, X. B., Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis, vol. 14, pp. 4767-4777, 2015.

Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk. A digital search was performed of the MEDLINE EMBASE, CNKI, and CBM databases to identify relevant articles published up to February 18, 2014.

Meta-analysis of differentially expressed genes in ankylosing spondylitis

Y. H. Lee and Song, G. G., Meta-analysis of differentially expressed genes in ankylosing spondylitis, vol. 14, pp. 5161-5170, 2015.

The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in ankylosing spondylitis (AS). We performed a meta-analysis using the integrative meta-analysis of expression data program on publicly available microarray AS Gene Expression Omnibus (GEO) datasets. We performed Gene Ontology (GO) enrichment analyses and pathway analysis using the Kyoto Encyclopedia of Genes and Genomes. Four GEO datasets, including 31 patients with AS and 39 controls, were available for the meta-analysis.

Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis

K. Cui, Ge, X. Y., and Ma, H. L., Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis, vol. 14, pp. 5210-5220, 2015.

The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify articles that have reported an association between the TNF-α +489 G/A polymorphism and COPD risk.

TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis

Y. H. Lee and Song, G. G., TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis, vol. 14, pp. 4966-4977, 2015.

The purpose of this study was to examine whether tu­mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex­amining the association between TNF-α -308 A/G and -238 A/G poly­morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-α -308 A al­lele and glaucoma [odds ratio (OR) = 1.403, 95% confidence inter­val (CI) = 0.784-2.513, P = 0.254].

FSHR gene Thr307Ala and Asn680Ser polymorphisms in infertile men: an association study in North China and meta-analysis

X. Q. Wu, Xu, S. M., Wang, Y. Q., Li, Q., Wang, Z. Q., Zhang, C. L., and Shen, Y., FSHR gene Thr307Ala and Asn680Ser polymorphisms in infertile men: an association study in North China and meta-analysis, vol. 14, pp. 5592-5601, 2015.

Male infertility is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between follicle stimulating hormone receptor (FSHR) gene polymorphisms and male infertility risk has attracted widespread attention due to the unique biological functions of FSH. The aim of this study was to further explore the associations between the Thr307Ala and Asn680Ser polymorphisms of the FSHR gene and male infertility.

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis

G. Tian, Li, X., Li, H., Wang, X., and Cheng, B., Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis, vol. 14, pp. 5501-5510, 2015.

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The National Center for Biotechnology Information Global Cross Database and Google Scholar database were searched for relative studies.

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