P.N. Mukhopadhyaya, A. Acharya, Y. Chavan, S.S. Purohit and A. Mutha
Published October 19, 2010
Genet. Mol. Res. 9 (4): 2060-2068 (2010)
DOI 10.4238/vol9-4gmr883
About the Authors
P.N. Mukhopadhyaya, A. Acharya, Y. Chavan, S.S. Purohit and A. Mutha
Corresponding author:
P.N. Mukhopadhyaya
E-mail: pnm6619@gmail.com
ABSTRACT
A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females). The genes and their corresponding single-nucleotide polymorphisms that we screened were VDR (rs 731236 and rs 1544410), IL-6 (rs 1800795), TCF7L2 (rs 7903146) and TNF-α (rs 1800629). The risk alleles were more frequent in the subjects with type 2 diabetes, except for the TNF-α gene, which was very infrequent in the population; the normal allele occurred at high and similar frequencies in both normal and diabetic individuals.
Key words: Insulin resistance; SNP; VDR; IL-6; TNF; TCF7L2.