Metastasis

PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer

F. S. Ramos, Serino, L. T. R., Carvalho, C. M. S., Lima, R. S., Urban, C. A., Cavalli, I. J., and Ribeiro, E. M. S. F., PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer, vol. 14, pp. 6960-6967, 2015.

Changes in the expression of the protein disulfide isomerase genes PDIA3 and PDIA6 may increase endoplasmic reticulum stress, leading to cellular instability and neoplasia. We evaluated the expression of PDIA3 and PDIA6 in invasive ductal carcinomas. Using reverse transcription-quantitative polymerase chain reaction, we compared the mRNA expression level in 45 samples of invasive ductal carcinoma with that in normal breast samples. Increased expression of the PDIA3 gene in carcinomas (P = 0.0009) was observed.

Study on serum proteomic features in patients with and without recurrence or metastasis after surgical resection of esophageal carcinoma

G. B. Zheng, Gao, C. F., Wang, X. L., Zhao, G., and Li, D. H., Study on serum proteomic features in patients with and without recurrence or metastasis after surgical resection of esophageal carcinoma, vol. 13, pp. 538-545, 2014.

The purpose of this study was to identify specific bio­markers for recurrence or metastasis of esophageal carcinoma in serum of patients subjected to esophagectomy. Surface-enhanced laser desorp­tion/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) combined with IMAC-Cu2+ ProteinChip array were performed for the serum protein profiling in patients after surgical resection of esophageal carcinoma. Two groups of patients were analyzed: 38 patients without recurrence or metastasis (Group 1) and 22 patients with recurrence or metastasis after resection (Group 2).

Characteristics and clinical significance of lymph node metastases near the recurrent laryngeal nerve from thoracic esophageal carcinoma

K. Ye, Xu, J. H., Sun, Y. F., Lin, J. A., and Zheng, Z. G., Characteristics and clinical significance of lymph node metastases near the recurrent laryngeal nerve from thoracic esophageal carcinoma, vol. 13, pp. 6411-6419, 2014.

This study aimed to evaluate the characteristics of lymph node (LN) metastases from thoracic esophageal carcinoma near the recurrent laryngeal nerve and the influence of these metastases on patient prognosis and to determine the reasonable regional LN dissection range. The clinical data from 120 patients who underwent resection for thoracic esophageal carcinoma were analyzed retrospectively.

Metastatic renal cell carcinoma to the left maxillary sinus

Y. - F. He, Chen, J., Xu, W. - Q., Ji, C. - S., Du, J. - P., Luo, H. - Q., and Hu, B., Metastatic renal cell carcinoma to the left maxillary sinus, vol. 13. pp. 7465-7469, 2014.

Metastatic tumors in the paranasal sinuses are very rare. The origin of metastatic tumors in the paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency for early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper, we deal with the case of a 35-year-old male patient who presented with a mass in the left maxillary region. The presence of a primary renal cell carcinoma was recognized only after surgical removal of the metastatic tumor.

Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma

X. Wang, Liu, M., and Zhao, C. Y., Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma, vol. 13, pp. 8002-8013, 2014.

We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) and their correlation with patient clinicopathological characteristics and overall survival. Immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) for ezrin and moesin were applied to 60 carcinoma tissues, adjacent normal tissues, and 33 metastatic lymph nodes. Survival functions were estimated using the Kaplan-Meier method and compared by the log-rank test.

S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer

Z. Hussain, Khan, M. I., Shahid, M., and Almajhdi, F. N., S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer, vol. 12, pp. 1106-1118, 2013.

DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloproteinase-2 (TIMP-2) is known to antagonize matrix metalloproteinase (MMP) activity and to suppress tumor growth, angiogenesis, invasion, and metastasis.

Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer

D. S. Vasconcelos, da Silva, F. P. E., Quintana, L. G., Anselmo, N. P., Othman, M. A. K., Liehr, T., and de Oliveira, E. H. C., Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer, vol. 12, pp. 2594-2600, 2013.

Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor gene TP53, located at 17p13.1, is either lost or mutated.

Elimination of breast tumor-associated chondroitin sulfate promotes metastasis

R. D. Prinz, Willis, C. M., Viloria-Petit, A., and Klüppel, M., Elimination of breast tumor-associated chondroitin sulfate promotes metastasis, vol. 10, pp. 3901-3913, 2011.

Breast cancer is one of the leading causes of cancer-related deaths amongst women in the USA. The tumor microenvironment has been suggested to be an attractive therapeutic target for treatment of cancers. The glycosaminoglycan chondroitin sulfate, as part of the cellular microenvironment, consists of long linear chains of repeating disaccharide units, which are covalently attached to core proteins to form chondroitin sulfate-proteoglycans.

Subscribe to Metastasis