Metastasis-associated gene 1

MTA1 promotes cell proliferation via DNA damage repair in epithelial ovarian cancer

Q. Y. Yang, Li, J. H., Wang, Q. Y., Wu, Y., Qin, J. L., Cheng, J. J., and Qiu, J., MTA1 promotes cell proliferation via DNA damage repair in epithelial ovarian cancer, vol. 13, pp. 10269-10278, 2014.

We examined whether metastasis-associated gene 1 (MTA1) promotes cell proliferation via DNA damage repair in ovarian cancer. MTA1 was successfully down-regulated using small interfering RNA in the epithelial ovarian cancer cell lines SKOV-3 and OVCAR-3. Cell growth was evaluated through MTT and colony formation assays. Fluorescence-activated cell sorting analysis was used to evaluate the distribution of cells in the cell cycle, and cytotoxicity assays were performed to study cell sensitivity to cisplatin.

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