Methylenetetrahydrofolate reductase

Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response

L. Yang, Wang, X. W., Zhu, L. P., Wang, H. L., Wang, B., Wu, T., Zhao, Q., JinSiHan, D. L. X. T., Wang, X. Y., Yang, L., Wang, X. W., Zhu, L. P., Wang, H. L., Wang, B., Wu, T., Zhao, Q., JinSiHan, D. L. X. T., and Wang, X. Y., Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response, vol. 15, p. -, 2016.

Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorphisms (C677T and A1298C) and breast cancer (BC) chemotherapy response.

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