MGMT

Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer

J. Jin, Xie, L., Xie, C. H., and Zhou, Y. F., Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer, vol. 13, pp. 4140-4145, 2014.

We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT and hMLH1 were detected. The proportions of DNA hypermethylation in MGMT and hMLH1 in cancer tissues were significantly higher than those in remote normal-appearing tissues.

Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels

N. Liu, Jiang, J., Song, Y. J., Zhao, S. G., Tong, Z. G., Song, H. S., Wu, H., Zhu, J. Y., Gu, Y. H., Sun, Y., Hua, W., and Qi, J. P., Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels, vol. 12, pp. 5160-5171, 2013.

Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation. As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate end-products.

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