Micronucleus

Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism

M. D. Martello, David, N., Matuo, R., Carvalho, P. C., Navarro, S. D., Monreal, A. C. D., Cunha-Laura, A. L., Cardoso, C. A. L., Kassuya, C. A. L., Oliveira, R. J., Martello, M. D., David, N., Matuo, R., Carvalho, P. C., Navarro, S. D., Monreal, A. C. D., Cunha-Laura, A. L., Cardoso, C. A. L., Kassuya, C. A. L., Oliveira, R. J., Martello, M. D., David, N., Matuo, R., Carvalho, P. C., Navarro, S. D., Monreal, A. C. D., Cunha-Laura, A. L., Cardoso, C. A. L., Kassuya, C. A. L., and Oliveira, R. J., Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism, vol. 15, p. -, 2016.

Campomanesia adamantium (Cambess.) O. Berg. is originally from Brazil. Its leaves and fruits have medicinal properties such as anti-inflammatory, antidiarrheal and antiseptic properties. However, the mutagenic potential of this species has been reported in few studies. This study describes the mutagenic/antimutagenic, splenic phagocytic, and apoptotic activities of C. adamantium hydroethanolic extract with or without cyclophosphamide in Swiss mice.

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