MicroRNA

Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population

X. H. Wang, Wang, F. R., Tang, Y. F., Zou, H. Z., and Zhao, Y. Q., Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population, vol. 13, pp. 5048-5054, 2014.

We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to be smokers and drinkers, have hepatitis B and C virus infections, and a family history of cancer.

Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression

B. S. Wang, Liu, Z., Xu, W. X., and Sun, S. L., Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression, vol. 13, pp. 5426-5440, 2014.

MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in controlling a variety of biological functions. Emerging evidence has shown that common genetic polymorphisms in miRNAs may be associated with the development of liver cancer; however, several individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the association between functional polymorphisms in miRNAs and susceptibility to liver cancer.

Bioinformatic analysis of miRNA expression patterns in TFF2 knock-out mice

Y. Yin, Shan, H. Q., Huang, W., Wu, Y. M., Lu, H., and Jin, Y., Bioinformatic analysis of miRNA expression patterns in TFF2 knock-out mice, vol. 13, pp. 8502-8510, 2014.

Trefoil factors, which bear a unique 3-loop trefoil domain, are a family of small secretory protease-resistant peptides (7-12 kDa) discovered in the 1980s. Trefoil factor 2 (TFF2) is a unique member of trefoil factors family that plays important roles in gastrointestinal mucosal defense and repair. However, few studies have characterized the miRNA expression patterns in TFF2 knock-out mice. In this study, we investigated the regulatory role of miRNAs in TFF2 knock-out mice.

Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis

Y. Kong, Wu, J. B., Wang, X., Zhao, J. F., Song, H., and Yuan, L. D., Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis, vol. 13, pp. 10162-10172, 2014.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'-untranslated region of the gene and may influence the binding of regulatory microRNAs (miRNAs) and OLR1 protein homeostasis. A number of studies have reported an association between this variant and AD.

Identification of UV-B-induced microRNAs in wheat

B. Wang, Sun, Y. F., Song, N., Wang, X. J., Feng, H., Huang, L. L., and Kang, Z. S., Identification of UV-B-induced microRNAs in wheat, vol. 12, pp. 4213-4221, 2013.

MicroRNAs (miRNAs) play critical roles in post-transcriptional gene regulation and act as important endogenous regulators to various stressors. Ultraviolet-B (UV-B) radiation is a major factor influencing crop growth and development. In this study, we isolated a novel wheat miRNA, named Tae-miR6000, and confirmed its expression diversity after UV-B treatments. Additionally, using the Northern blotting technique, we found that six miRNAs were highly responsive to UV-B stress in wheat.

Inhibitory effect of microRNA-24 on fatty acid-binding protein expression on 3T3-L1 adipocyte differentiation

M. Kang, Yan, L. M., Li, Y. M., Zhang, W. Y., Wang, H., Tang, A. Z., and Ou, H. S., Inhibitory effect of microRNA-24 on fatty acid-binding protein expression on 3T3-L1 adipocyte differentiation, vol. 12, pp. 5267-5277, 2013.

We examined the effect of microRNAs on 3T3-L1 adipocyte differentiation and expression of adipocyte-specific gene fatty acid-binding protein 4 (FABP4). We screened and identified adipo-related microRNAs during 3T3-L1 adipocyte differentiation with a microRNA microarray. High expression plasmids of miR-24 and miR-21 were constructed and transfected into 3T3-L1 preadipocytes by lipofectamine. The effects of miR-24 and miR-21 on 3T3-L1 adipocyte differentiation were observed, and the protein and mRNA expression levels of FABP4 and AP-1 were determined.

MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis

Y. Yang, Qiu, J., Kan, Q., Zhou, X. - G., and Zhou, X. - Y., MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis, vol. 12, pp. 5195-5206, 2013.

Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was conducted to review published miRNA expression profiling studies that compared miRNA expression profiles between BPD lung tissues and normal lung tissues.

Predicting the target genes of microRNA based on microarray data

B. Cao, Ji, T., Zhou, B., Zou, J., and Jiao, G. Q., Predicting the target genes of microRNA based on microarray data, vol. 12, pp. 6059-6066, 2013.

MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides in length, which play important roles in regulating gene expression post-transcriptionally. Several computational methods and algorithms have been developed to predict miRNA targets. In this study, we described a method that can be used to integrate miRNA target prediction data from multiple sources and gene expression data to predict target genes of particular miRNAs. We used hsa-miR-375 as an example to test the feasibility of our method.

Serum microRNA expression in pregnancies with preeclampsia

T. Gunel, Zeybek, Y. G., Akçakaya, P., Kalelioglu, I., Benian, A., Ermis, H., and Aydinli, K., Serum microRNA expression in pregnancies with preeclampsia, vol. 10, pp. 4034-4040, 2011.

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir-152 and mir-210.

miRNApath: a database of miRNAs, target genes and metabolic pathways

A. O. Chiromatzo, Oliveira, T. Y. K., Pereira, G., Costa, A. Y., Montesco, C. A. E., Gras, D. E., Yosetake, F., Vilar, J. B., Cervato, M., Prado, P. R. R., Cardenas, R. G. C. C. L., Cerri, R., Borges, R. L., Lemos, R. N., Alvarenga, S. M., Perallis, V. R. C., Pinheiro, D. G., Silva, I. T., Brandão, R. M., Cunha, M. A. V., Giuliatti, S., and Silva, Jr, W. A., miRNApath: a database of miRNAs, target genes and metabolic pathways, vol. 6, pp. 859-865, 2007.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression and hence play important roles in metabolic pathways. Recent studies have evidenced the interrelation of miRNAs with cell proliferation, differentiation, development, and diseases. Since they are involved in gene regulation, they are intrinsically related to metabolic pathways. This leads to questions that are particularly interesting for investigating medical and laboratorial applications.

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