Microsatellite instability

Analysis of the role of hMLH1 hypermethylation and microsatellite instability in meningioma progression

M. N. Chen, Wang, P., Zhang, J., Zhou, B. Y., Mao, Q., and Liu, Y. H., Analysis of the role of hMLH1 hypermethylation and microsatellite instability in meningioma progression, vol. 11, pp. 3933-3941, 2012.

We investigated a possible role of hMLH1 hypermethylation and microsatellite instability in meningioma progression. Fifty meningomas were examined for methylation of hMLH1 using a methylation-specific PCR; 43 of them were analyzed for microsatellite instability using nine microsatellite markers. Loss of heterozygosity on chromosome 22q was detected using two markers. Two atypical meningiomas showed microsatellite instability at four loci; one was methylated on hMLH1 and the other was unmethylated.

Loss of heterozygosity on chromosome 5 in Iranian esophageal cancer patients

F. Attaran-Bandarabadi, Ziaee, A. A., Yazdanbod, M., Shahpanah, M., Setayeshgar, A., and Nassiri, M., Loss of heterozygosity on chromosome 5 in Iranian esophageal cancer patients, vol. 10, pp. 2316-2325, 2011.

There is a high incidence of esophageal squamous cell carcinoma (ESCC) in Iran. Non-functionality of some tumor suppressor genes has been reported in esophageal cancer. Loss of heterozygosity on chromosome 5 has also been reported in esophageal carcinomas. We assessed loss of heterozygosity along a region of the long arm of chromosome 5 (5q), from 5q23.1 to 5q23.2, by PCR amplifying DNA fragments of tumor tissues from patients with ESCC and their corresponding normal samples.

High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran

M. Moghbeli, Moaven, O., Dadkhah, E., Farzadnia, M., Roshan, N. M., Asadzadeh-Aghdaee, H., Bahar, M. M., Raeisossadati, R., Forghanifard, M. M., Bakhtiari, S. R. E. A., Baradaran, A., and Abbaszadegan, M. R., High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran, vol. 10, pp. 3520-3529, 2011.

Microsatellite instability in sporadic colorectal cancer patients was assessed, and the clinicopathological associations were evaluated in northeastern Iran, which is a high-risk region for gastrointestinal malignancies. Microsatellite instability (MSI) status of tumoral tissue, compared to normal tissue, was assessed with a standard panel of MSI markers on paraffin-embedded surgically resected tissues from 67 consecutive sporadic colorectal cancer patients. Eleven of the patients were under 40 years old.

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