Migration

Effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma A375 cells

Y. P. Zhang, Li, Y. Q., Lv, Y. T., and Wang, J. M., Effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma A375 cells, vol. 14, pp. 1056-1067, 2015.

Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentrations of curcumin. We observed the cellular morphology and determined the migration, invasion, proliferation, and apoptosis of A375 cells in vitro.

Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma

Z. Z. Cai, Xu, L. B., Cai, J. L., Wang, J. S., Zhou, B., and Hu, H., Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma, vol. 14, pp. 2707-2715, 2015.

Pancreatic ductal adenocarcinoma (PDAC) is charac­terized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pan­creatic tissue samples (P = 0.0073), respectively. There were signifi­cant correlations between Rab23 expression and unfavorable variables, including cancer differentiation level (P = 0.0089), lymph nodal (P = 0.0099), and distant metastases (P = 0.0173).

Overexpression of the growth arrest-specific homeobox gene Gax inhibits proliferation, migration, cell cycle progression, and apoptosis in serum-induced vascular smooth muscle cells

H. Zheng, Xue, S., Hu, Z. L., Shan, J. G., and Yang, W. G., Overexpression of the growth arrest-specific homeobox gene Gax inhibits proliferation, migration, cell cycle progression, and apoptosis in serum-induced vascular smooth muscle cells, vol. 13, pp. 1993-2008, 2014.

The Gax gene has been implicated in a variety of cell-developmental and biological processes, and aberrant Gax expression is linked to many diseases. In this study, to provide important insights for Gax-based gene therapy in vein graft restenosis and its anti-restenotic mechanism, we used rabbit vascular smooth muscle cells (VSMCs) to investigate the effects of Gax overexpression on proliferation, migration, cell cycle, and apoptosis in a serum-stimulated culture.

Inverted migration of rare whisker sheatfish in Nong-Han Lake, northeastern Thailand: Implications for conservation

P. Phongkaew, Arunyawat, U., Swatdipong, A., and Hongtrakul, V., Inverted migration of rare whisker sheatfish in Nong-Han Lake, northeastern Thailand: Implications for conservation, vol. 13, pp. 7492-7502, 2014.

Nong-Han Lake, Thailand, sustains the whisker sheatfish (Micronema bleekeri Günther, 1864), which is a rare species of freshwater catfish. Wild-caught whisker sheatfish has been intensively harvested to meet market demand; yet, genetic information about this species remains unknown. To assist with the in situ conservation of whisker sheatfish populations in Nong-Han Lake, 35 and 34 individuals from the middle (MN) and lower (LN) areas of the lake, respectively, were studied using 7 microsatellite loci.

Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression

G. - F. Li, Qian, T. - L., Li, G. - S., Yang, C. - X., Qin, M., Huang, J., Sun, M., and Han, Y. - Q., Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression, vol. 11, pp. 77-86, 2012.

Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproate on breast cancer are insufficient in both animals and humans; studies have yielded conflicting conclusions. In particular, little is known about the association between expression of the metastasis suppressor Nm23H1 gene and breast cancer.

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