miR-152

A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells

Y. H. Cao, Li, D. G., Xu, B., Wang, M. Q., Zhen, N., Man, L. X., Zhang, Y. Y., Chi, M., Cao, Y. H., Li, D. G., Xu, B., Wang, M. Q., Zhen, N., Man, L. X., Zhang, Y. Y., and Chi, M., A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells, vol. 15, p. -, 2016.

Brain damage caused by perinatal asphyxia is dangerous for neonatal infants, but the mechanism by which it occurs remains elusive. In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured in vitro. Analysis of the sequence of miR-152 revealed that the phosphatase and tensin homolog gene (PTEN) is probably the target of miR-152 both in humans and rats.

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